The long-term quality of life in patients with persistent inflammation-immunosuppression and catabolism syndrome after severe acute pancreatitis: A retrospective cohort study

Purpose: To explore clinical characteristics and long-term quality of life (QOL) in severe acute pancreatitis (SAP) patients with persistent inflammation-immunosuppression and catabolism syndrome (PICS). Materials and methods: SAP patients admitted to ICU were eligible for the retrospective cohort study if they needed prolonged intensive care (>14 days). Post-ICU QOL was assessed by a questionnaire, including 36-item Short Form Health Survey (SF-36) and record of re-work in a long-term follow-up. Results: 214 SAP patients were enrolled, in which 149 (69.6%) patients met the criteria of PICS. PICS patients had more complications and ICU days compared to non-PICS patients (P < 0.001), and their post-ICU mortality was higher (P = 0.046). When adjusted for confounders, PICS was independently associated with higher post-ICU mortality (hazard ratio 4.5; 95% CI, 1.2 to 16.3; P = 0.024). The 36-item Short Form Health Survey (SF-36) score was lower for PICS group in six subscales (P < 0.001). Only 28.8% patients in the PICS group returned to work compared to 60% patients in the non-PICS group (P = 0.001) Conclusions: SAP patients with prolonged ICU stay had a high morbidity of PICS, which was a risk factor for the post-ICU mortality and poor long-term QOL. (c) 2017 Elsevier Inc. All rights reserved.