A20 is a negative regulator of BCL10- and CARMA3-mediated activation of NF-κB

被引：33

作者：

Stilo, Romania ^{[1
,4
]}

Varricchio, Ettore ^{[1
]}

Liguoro, Domenico ^{[2
]}

Leonardi, Antonio ^{[3
]}

Vito, Pasquale ^{[1
,4
]}

机构：

[1] Univ Sannio Benevento, Dip Sci Biol Ambientali, I-82100 Benevento, Italy

[2] Ctr Endocrinol Oncol Sperimentale, Naples, Italy

[3] Univ Napoli Federico II, Dip Biol & Patol Cellulare & Mol, I-80131 Naples, Italy

[4] BioGeM Consortium, I-83031 Ariano Irpino, Italy

来源：

JOURNAL OF CELL SCIENCE | 2008年 / 121卷 / 08期

关键词：

A20; BCL10; CARMA;

D O I：

10.1242/jcs.021105

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The molecular complex containing CARMA proteins, BCL10 and TRAF6 has been identified recently as a key component in the signal transduction pathways that regulate activation of the nuclear factor kappa B (NF-kappa B) transcription factor. Here, we report that the inducible protein A20 negatively regulates these signaling cascades by means of its deubiquitylation activity. We show that A20 perturbs assembly of the complex containing CARMA3, BCL10 and IKK gamma/NEMO, thereby suppressing activation of NF-kappa B. Together, our results further define the molecular mechanisms that control activation of NF-kappa B and reveal a function for A20 in the regulation of CARMA and BCL10 activity in lymphoid and non-lymphoid cells.

引用

收藏

页码：1165 / 1171

页数：7

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