Aneurysmal bone cyst with chromosomal changes involving 7q and 16p

被引：32

作者：

Baruffi, MR

Neto, JB

Barbieri, CH

Casartelli, C

机构：

[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Genet, BR-14049 Ribeirao Preto, Brazil

[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pathol, BR-05508 Sao Paulo, Brazil

[3] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Surg, Div Orthoped, BR-05508 Sao Paulo, Brazil

来源：

CANCER GENETICS AND CYTOGENETICS | 2001年 / 129卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1016/S0165-4608(01)00453-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An aneurysmal bone cyst was submitted to cytogenetic analysis. The modal chromosome number was 46. The composite karyotype was 40 similar to 48,XY.-Y[4],-6[3],del(7)(q32)[3],-9[3],+12[2],+13[2], inv(16)(p13.1q24)[4],-17[3],-19[4],-20[3][cp13]. The clonal structural changes detected were del(7)(q32) and inv(16)(p13.1q24). The breakpoints involved affected areas to which important genes for cell cycle regulation have been mapped. There is only one report in the literature of three aneurysmal bone cysts presenting clonal karyotypic alterations. The cytogenetic study of the aneurysmal bone cyst reported here showed different results when compared to those previously described in the literature. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：177 / 180

页数：4

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