Accumulation of 2-hydroxyglutarate in gliomas correlates with survival: a study by 3.0-tesla magnetic resonance spectroscopy

被引：46

作者：

Natsumeda, Manabu ^{[1
]}

Igarashi, Hironaka ^{[2
]}

Nomura, Toshiharu ^{[1
]}

Ogura, Ryosuke ^{[1
]}

Tsukamoto, Yoshihiro ^{[1
]}

Kobayashi, Tsutomu ^{[1
]}

Aoki, Hiroshi ^{[1
]}

Okamoto, Kouichirou ^{[1
]}

Kakita, Akiyoshi ^{[3
]}

Takahashi, Hitoshi ^{[3
]}

Nakada, Tsutomu ^{[2
]}

Fujii, Yukihiko ^{[1
]}

机构：

[1] Niigata Univ, Brain Res Inst, Dept Neurosurgery, Niigata, Japan

[2] Niigata Univ, Brain Res Inst, Ctr Integrated Brain Sci, Niigata, Japan

[3] Niigata Univ, Brain Res Inst, Dept Pathol, Niigata, Japan

来源：

ACTA NEUROPATHOLOGICA COMMUNICATIONS | 2014年 / 2卷

关键词：

Glioma; MRS; 2-hydroxyglutarate; IDH mutation; Prognostic marker; IN-VIVO; ONCOMETABOLITE; 2-HYDROXYGLUTARATE; IDH1; MUTATIONS; MUTANT IDH1; GROWTH; EXPRESSION; INHIBITOR; CELLS;

D O I：

10.1186/s40478-014-0158-y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Introduction: Previous magnetic resonance spectroscopy (MRS) and mass spectroscopy studies have shown accumulation of 2-hydroxyglutarate (2HG) in mutant isocitrate dehydrogenase (IDH) gliomas. IDH mutation is known to be a powerful positive prognostic marker in malignant gliomas. Hence, 2HG accumulation in gliomas was assumed to be a positive prognostic factor in gliomas, but this has not yet been proven. Here, we analyzed 52 patients harboring World Health Organization (WHO) grade II and III gliomas utilizing 3.0-tesla MRS. Results: Mutant IDH gliomas showed significantly higher accumulation of 2HG (median 5.077 vs. 0.000, p = 0.0002, Mann-Whitney test). 2HG was detectable in all mutant IDH gliomas, whereas in 10 out of 27 (37.0%) wild-type IDH gliomas, 2HG was below the detectable range (2HG = 0) (p = 0.0003, chi-squared test). Screening for IDH mutation by 2HG analysis was highly sensitive (cutoff 2HG = 1.489 mM, sensitivity 100.0%, specificity 72.2%). Gliomas with high 2HG accumulation had better overall survival than gliomas with low 2HG accumulation (p = 0.0401, Kaplan-Meier analysis). Discussion: 2HG accumulation detected by 3.0-tesla MRS not only correlates well with IDH status, but also positively correlates with survival in WHO grade II and III gliomas.

引用

页数：7

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