Necrosulfonamide Selectively Induces DNA Double-Strand Breaks in Acute Myeloid Leukemia Cells

被引：6

作者：

Chen, Shaokun ^{[1
]}

Lai, Weiyi ^{[2
]}

Li, Xiangjun ^{[1
]}

Wang, Hailin ^{[1
,2
,3
]}

机构：

[1] Univ Chinese Acad Sci, Sch Chem Sci, Beijing 100049, Peoples R China

[2] Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 10085, Peoples R China

[3] UCAS, Inst Adv Study, Inst Environm & Hlth, Hangzhou 310000, Peoples R China

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2022年 / 35卷 / 03期

基金：

中国国家自然科学基金;

关键词：

MIXED LINEAGE KINASE; INHIBITION; APOPTOSIS; PROTEIN; REPAIR; NECROPTOSIS; CANCER; DAMAGE; DEATH;

D O I：

10.1021/acs.chemrestox.2c00044

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy that causes endless pain for patients and accounts for thousands of deaths worldwide. The development of an effective AML treatment is a topic of ongoing interest. Here, we demonstrated that a pyroptosis inhibitor necrosulfonamide (NSA) can selectively induce highly toxic double-strand breaks and kill AML cells. Mechanistically, reactive oxygen species (ROS) were the key effectors mediating the toxicity of NSA. These results probably indicate that NSA is a novel candidate for the treatment of AML.

引用

页码：387 / 391

页数：5

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