Mild and Metal-Free Cross-Dehydrogenative Coupling of Nitrogen Heteroarenes with Aldehydes Enabled by Structural Hybridization of Promoting Reagents

被引：0

作者：

Zhao, Jianhong ^{[2
]}

Qian, Kun ^{[3
]}

Tong, Mengchao ^{[1
]}

Yuan, Qiyang ^{[2
]}

Zhang, Yongqiang ^{[1
]}

机构：

[1] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Me, Shanghai 200237, Peoples R China

[2] East China Univ Sci & Technol, Sch Pharm, Lab Green Pharmaceut Proc & Technol, Shanghai 200237, Peoples R China

[3] Shanghai Pharmaceut Sch, Shanghai 200135, Peoples R China

来源：

CHEMISTRYSELECT | 2022年 / 7卷 / 08期

基金：

中国国家自然科学基金;

关键词：

cross-dehydrogenative coupling; nitrogen heteroarenes; aldehydes; structural hybridization; promoting reagents; BETA-PHENYLETHYLAMINES; HETEROCYCLES; ETHERS; ACYLATION;

D O I：

10.1002/slct.202104172

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mild and metal-free cross-dehydrogenative coupling reaction of nitrogen heteroarenes with aldehydes has been developed by the structural hybridization of promoting reagents. The procedure is environmentally benign, cost-effective and industrially scalable, which allows the direct acylation of electron-deficient nitrogen heteroarenes in moderate to good yields. Furthermore, the synthetic utility of this new method in the synthesis of a variety of pharmaceutically relevant isoquinoline alkaloids has been also demonstrated.

引用

页数：5

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