Cell Surface as a Fractal: Normal and Cancerous Cervical Cells Demonstrate Different Fractal Behavior of Surface Adhesion Maps at the Nanoscale

被引:78
作者
Dokukin, M. E. [1 ]
Guz, N. V. [1 ]
Gaikwad, R. M. [1 ]
Woodworth, C. D. [2 ]
Sokolov, I. [1 ,3 ]
机构
[1] Clarkson Univ, Dept Phys, Potsdam, NY 13699 USA
[2] Clarkson Univ, Dept Biol, Potsdam, NY 13699 USA
[3] Clarkson Univ, Nanoengn & Biotechnol Labs Ctr NABLAB, Potsdam, NY 13699 USA
关键词
SELF-AFFINE FRACTALS; DIMENSIONS; SMEARS;
D O I
10.1103/PhysRevLett.107.028101
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
Here we show that the surface of human cervical epithelial cells demonstrates substantially different fractal behavior when the cell becomes cancerous. Analyzing the adhesion maps of individual cervical cells, which were obtained using the atomic force microscopy operating in the HarmoniX mode, we found that cancerous cells demonstrate simple fractal behavior, whereas normal cells can only be approximated at best as multifractal. Tested on similar to 300 cells collected from 12 humans, the fractal dimensionality of cancerous cells is found to be unambiguously higher than that for normal cells.
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页数:4
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