Organization and function of the FKBP52 and FKBP51 genes

被引：61
作者：
Cioffi, Donna L. [2 ,3 ]
Hubler, Tina R. [4 ]
Scammell, Jonathan G. [1 ]
机构：
[1] Univ S Alabama, Coll Med, Dept Comparat Med & Pharmacol, Mobile, AL 36688 USA
[2] Univ S Alabama, Coll Med, Dept Biochem, Mobile, AL 36688 USA
[3] Univ S Alabama, Coll Med, Dept Mol Biol, Mobile, AL 36688 USA
[4] Univ N Alabama, Dept Biol, Florence, AL 35632 USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2011年 / 11卷 / 04期
基金：
美国国家卫生研究院;
关键词：
FK506-BINDING IMMUNOPHILIN FKBP51; PROTEIN; CHANNELS; EXPRESSION; BINDING;
D O I：
10.1016/j.coph.2011.03.013
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Best established as components of steroid hormone receptor complexes, it is now clear that the large molecular weight immunophilins, FKBP52 and FKBP51, play important regulatory roles elsewhere in the cell. This review outlines what is known about the organization of the genes, FKBP4 and FKBP5, respectively, encoding these proteins and describes their diverse actions in the nervous system, reproduction, and cancer. The organization of FKBP4 and FKBP5 is very similar among the chordates, and gene expression is influenced by both genetic and epigenetic mechanisms. Recent studies identifying roles of FKBP52 and FKBP51 in the regulation of the microtubule-associated protein tau and microtubule assembly are discussed, as is their interaction with and influence on the transient receptor potential canonical (TRPC) subfamily of ion channel proteins.
引用
收藏
页码：308 / 313
页数：6
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