A novel systemic inflammation response index (SIRI) for predicting postoperative survival of patients with esophageal squamous cell carcinoma

Background: Inflammation is closely associated with the initiation and development of tumors. Based on the counts of peripheral neutrophils, monocytes and lymphocytes, we established a new systemic inflammation response index (SIRI) to predict postoperative survival of patients with esophageal squamous cell carcinoma (ESCC). Methods: A total of 916 ESCC patients treated with radical esophagectomy were enrolled in the present study. Results: Survival analysis indicated that the median overall survival (OS) in patients with SIRI <= 1.2 was significantly higher than that in patients with SIRI > 1.2. The nomogram including SIRI could more accurately predict OS compared with the TNM staging system. In addition, the changes of SIRI from baseline to 8 weeks after the operation were correlated with patient survival. The patients with an increase in SIRI > 75% had worse OS compared with those with no change, while the patients with a decrease in SIRI > 75% or in the scope of 25% similar to 75% exhibited better OS. Conclusions: SIRI was an independent prognostic index of ESCC patients after the radical resection. The nomogram integrating the SIRI could help clinicians to screen the high-risk patients and formulate the individualized treatment schemes.