Synthesis, Reactions and Antibacterial Activity of 3-Acetyl[1,2,4]triazolo[3,4-a]isoquinoline Derivatives using Chitosan as Heterogeneous Catalyst under Microwave Irradiation

被引：27

作者：

Hassaneen, Hamdi M. ^{[1
]}

Hassaneen, Huwaida M. E. ^{[1
]}

Mohammed, Yasmin Sh. ^{[1
]}

Pagni, Richard M. ^{[2
]}

机构：

[1] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt

[2] Univ Tennessee, Dept Chem, Knoxville, TN 37996 USA

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2011年 / 66卷 / 03期

关键词：

1,2,4]Triazolo[3,4-a]isoquinoline; Enaminones; Hydrazinolysis; Hydrazonoyl Chlorides; Cycloaddition Reaction; Chitosan; Hydroximoyl Chloride; HETEROCYCLES; REACTIVITY; 1-METHYLISOQUINOLINE; CHLORIDES;

D O I：

10.5560/ZNB.2011.66b0299

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

3-Acetyl[1,2,4]tritizolo[3,4-a]isoquinolines were prepared using chitosan as a catalyst. These compounds were used to prepare a novel series of enaminones 5, and their reactions with hydrazonoyl halides 1 and 11 gave triazoloisoquinolines 8 and 13, respectively, with a carbonylpyrazole side chain. Hydrazinolysis of 8 and 13 gave the pyrazolopyridazines 10 and pyrazolopyridazinones 14. Reaction of 5 with hydroximoyl halides 15 led to triazoloisoquinoline 16 with a carbonylisoxazole side chain. Antibacterial effects of compounds 8 and 10 were studied.

引用

页码：299 / 310

页数：12

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