T follicular helper cells in the humoral immune response to SARS-CoV-2 infection and vaccination

被引：28
|
作者：
Koutsakos, Marios [1 ]
Lee, Wen Shi [1 ]
Wheatley, Adam K. [1 ]
Kent, Stephen J. [1 ,2 ,3 ,4 ]
Juno, Jennifer A. [1 ]
机构：
[1] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic 3000, Australia
[2] Monash Univ, Melbourne Sexual Hlth Ctr, Melbourne, Vic, Australia
[3] Monash Univ, Alfred Hosp, Dept Infect Dis, Melbourne, Vic, Australia
[4] Monash Univ, Cent Clin Sch, Melbourne, Vic, Australia
来源：
JOURNAL OF LEUKOCYTE BIOLOGY | 2022年 / 111卷 / 02期
基金：
英国医学研究理事会;
关键词：
CD4+T cells; COVID-19; SARS-CoV-2; T follicular helper cells; CXC CHEMOKINE RECEPTOR-5; TFH CELLS; B-CELLS; ANTIBODY; CORRELATE;
D O I：
10.1002/JLB.5MR0821-464R
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Vaccination remains the most effective mechanism to reduce the impact of COVID-19. Induction of neutralizing antibodies is a strong correlate of protection from infection and severe disease. An understanding of the cellular events that underpin the generation of effective neutralizing antibodies is therefore key to the development of efficacious vaccines that target emerging variants of concern. Analysis of the immune response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and vaccination has identified circulating T follicular helper cells (cT(FH)) as a robust correlate of the neutralizing antibody response. Here, we discuss the analysis of cT(FH) cells and their lymphoid counterparts in human humoral immune responses during COVID-19, and in response to vaccination with SARS-CoV-2 spike. We discuss the phenotypic heterogeneity of cT(FH) cells and the utility of cT(FH) subsets as informative biomarkers for development of humoral immunity. We posit that the analysis of the most effective cT(FH) will be critical to inducing durable immunity to new variants of SARS-CoV-2.
引用
收藏
页码：355 / 365
页数：11
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