Thermal and Microwave-Assisted Rapid Syntheses of Substituted Imidazo[1,2-a]pyridines Under Solvent- and Catalyst-Free Conditions

被引：56
|
作者：
Chunavala, Kaushik C. [1 ]
Joshi, Girdhar [1 ]
Suresh, Eringathodi [1 ]
Adimurthy, Subbarayappa [1 ]
机构：
[1] Cent Salt & Marine Chem Res Inst CSIR, Bhavnagar 364002, Gujarat, India
来源：
SYNTHESIS-STUTTGART | 2011年 / 04期
关键词：
aminopyridines; alpha-bromo-beta-keto esters; imidazo[1,2-a]pyridines; microwave irradiation; solvent-free; thermal; ONE-POT SYNTHESIS; C-NUCLEOSIDES; ANTIVIRAL ACTIVITY; SELECTIVE LIGANDS; BINDING-AFFINITY; DERIVATIVES; 2-AMINOPYRIDINES; INHIBITORS; ALDEHYDES; SERIES;
D O I：
10.1055/s-0030-1258405
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Thermal and microwave-assisted rapid syntheses of highly substituted imidazo[1,2-a]pyridine derivatives by reaction of aminopyridines and alpha-bromo-beta-keto esters under solvent-free conditions are described. Reactions carried out under microwave irradiation give the highest yields of products in reaction times of less than two minutes.
引用
收藏
页码：635 / 641
页数：7
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