Thermal and Microwave-Assisted Rapid Syntheses of Substituted Imidazo[1,2-a]pyridines Under Solvent- and Catalyst-Free Conditions

被引：56

作者：

Chunavala, Kaushik C. ^{[1
]}

Joshi, Girdhar ^{[1
]}

Suresh, Eringathodi ^{[1
]}

Adimurthy, Subbarayappa ^{[1
]}

机构：

[1] Cent Salt & Marine Chem Res Inst CSIR, Bhavnagar 364002, Gujarat, India

来源：

SYNTHESIS-STUTTGART | 2011年 / 04期

关键词：

aminopyridines; alpha-bromo-beta-keto esters; imidazo[1,2-a]pyridines; microwave irradiation; solvent-free; thermal; ONE-POT SYNTHESIS; C-NUCLEOSIDES; ANTIVIRAL ACTIVITY; SELECTIVE LIGANDS; BINDING-AFFINITY; DERIVATIVES; 2-AMINOPYRIDINES; INHIBITORS; ALDEHYDES; SERIES;

D O I：

10.1055/s-0030-1258405

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Thermal and microwave-assisted rapid syntheses of highly substituted imidazo[1,2-a]pyridine derivatives by reaction of aminopyridines and alpha-bromo-beta-keto esters under solvent-free conditions are described. Reactions carried out under microwave irradiation give the highest yields of products in reaction times of less than two minutes.

引用

页码：635 / 641

页数：7

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