Hand-Foot Syndrome Presentation Post-Capecitabine Treatment in a Black Patient

被引：3
作者：
Whorton, Allison E. [1 ]
Razzak, Abrahim N. [1 ]
Jha, Pinky [2 ]
机构：
[1] Med Coll Wisconsin, Sch Med, Milwaukee, WI 53226 USA
[2] Med Coll Wisconsin, Internal Med, Milwaukee, WI 53226 USA
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 07期
关键词：
emollient; diagnosis criteria; metaplastic breast cancer; cutaneous hyperpigmentation; chemotherapy response; chemotherapy-related toxicity; capecitabine side effects; PREVENTION;
D O I：
10.7759/cureus.26891
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Palmar-plantar erythrodysesthesia, commonly known as hand-foot syndrome (HFS), is a side-effect of cancer chemotherapeutic agents such as capecitabine. Patients with HFS oftentimes present with palmoplantar numbness, tingling, burning pain, and/or hyperpigmentation; in advanced grades, blistering and ulceration may occur. In this article, we present the case of a Black patient with grade 1 HFS post-capecitabine treatment for metastasized breast cancer. Prompt recognition for atypical HFS symptom presentation in people of color and discontinuation of capecitabine with supportive treatment can prevent progression to grade 2+ HFS that limits activities of daily living (ADLs).
引用
收藏
页数：5
相关论文
共 10 条
  • [1] Racial and ethnic differences in capecitabine toxicity in patients with gastrointestinal tract cancers
    Brazelton, Alicia
    Yande, Soham
    Pope, Rita
    Johnson, Michael L.
    Musher, Benjamin
    Trivedi, Meghana, V
    [J]. ANNALS OF GASTROENTEROLOGY, 2022, 35 (02): : 182 - 186
  • [2] Clinical evidence of prevention strategies for capecitabine-induced hand-foot syndrome
    Huang, Xuan-Zhang
    Chen, You
    Chen, Wen-Jun
    Zhang, Xi
    Wu, Cong-Cong
    Wang, Zhen-Ning
    Wu, Jian
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2018, 142 (12) : 2567 - 2577
  • [3] Palmar-plantar erythrodysesthesia syndrome following treatment with high-dose methotrexate or high-dose cytarabine
    Karol, Seth E.
    Yang, Wenjian
    Smith, Colton
    Cheng, Cheng
    Stewart, Clinton F.
    Baker, Sharyn D.
    Sandlund, John T.
    Rubnitz, Jeffrey E.
    Bishop, Michael W.
    Pappo, Alberto S.
    Jeha, Sima
    Pui, Ching-Hon
    Relling, Mary V.
    [J]. CANCER, 2017, 123 (18) : 3602 - 3608
  • [4] Palmar-plantar erythrodysesthesia associated with capecitabine chemotherapy: a case report
    Kigen, Gabriel
    Busakhala, Naftali
    Njiru, Evangeline
    Chite, Fredrick
    Loehrer, Patrick
    [J]. PAN AFRICAN MEDICAL JOURNAL, 2015, 21
  • [5] Management of cytotoxic chemotherapy-induced hand-foot syndrome
    Kwakman, Johannes J. M.
    Elshot, Yannick S.
    Punt, Cornelis J. A.
    Koopman, Miriam
    [J]. ONCOLOGY REVIEWS, 2020, 14 (01) : 57 - 63
  • [6] Possible Pathways of Capecitabine-Induced Hand-Foot Syndrome
    Lou, Yan
    Wang, Qjan
    Zheng, Jinqi
    Hu, Haihong
    Liu, Lin
    Hong, Dongsheng
    Zeng, Su
    [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 2016, 29 (10) : 1591 - 1601
  • [7] Narasimhan P, 2004, CUTIS, V73, P101
  • [8] Capecitabine and hand-foot syndrome
    Saif, Muhammad Wasif
    [J]. EXPERT OPINION ON DRUG SAFETY, 2011, 10 (02) : 159 - 169
  • [9] Atypical Hand-and-Foot syndrome in an African American Patient treated with Capecitabine with normal DPD activity: Is there an ethnic disparity?
    Saif, Muhammad Wasif
    Sandoval, Amanda
    [J]. CUTANEOUS AND OCULAR TOXICOLOGY, 2008, 27 (04) : 311 - 315
  • [10] Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine-Induced Hand-Foot Syndrome A Randomized Clinical Trial
    Yap, Yoon-Sim
    Kwok, Li-Lian
    Syn, Nicholas
    Chay, Wen Yee
    Chia, John Whay Kuang
    Tham, Chee Kian
    Wong, Nan Soon
    Lo, Soo Kien
    Dent, Rebecca Alexandra
    Tan, Sili
    Mok, Zuan Yu
    Koh, King Xin
    Toh, Han Chong
    Koo, Wen Hsin
    Loh, Marie
    Ng, Raymond Chee Hui
    Choo, Su Pin
    Soong, Richie Chuan Teck
    [J]. JAMA ONCOLOGY, 2017, 3 (11) : 1538 - 1545
1