The deposition of amyloid beta peptide (A beta) in the form of plaques in the brain is a hallmark of Alzheimer's disease (AD). Neprilysin is the major A beta-degradating enzyme and reduction in neprilysin activity could contribute to Alzheimer's by increasing the steady-state level of A beta. To provide further evidence for the role of neprilysin in AD we genotyped 22 polymorphisms, 21 SNPs and the GT repeat in the promoter region, across the neprilysin gene in 298 Caucasian sporadic Alzheimer's patients and 298 age-matched controls. Several SNPs showed genotypic and allelic association to AD. SNP rs 1836915, in linkage disequilibrium block 2, showed the greatest extent of genotypic association with AD (p = 0.0076). We were unable to replicate any of the SNPs that were previously reported as putatively associated with AD. However, these novel findings add to the weight of evidence supporting the involvement of neprilysin in the aetiology of Alzheimer's disease. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
机构:
Cent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Zhang, Feng
Liu, Xiaowei
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Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Liu, Xiaowei
Wang, Bailing
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Qingdao Mental Hlth Ctr, Qingdao, Shandong, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Wang, Bailing
Cheng, Zaohuo
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Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Cheng, Zaohuo
Zhao, Xingfu
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Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Zhao, Xingfu
Zhu, Jianzhong
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Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Zhu, Jianzhong
Wang, Degang
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Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Wang, Degang
Wang, Ying
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Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Wang, Ying
Dong, Aiguo
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Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Dong, Aiguo
Li, Pengpeng
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Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Li, Pengpeng
Jin, Chunhui
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Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
机构:
CHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USACHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
David, Renaud
Friedman, Leah
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Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
VA Palo Alto Hlth Care Syst, Psychiat Serv, Palo Alto, CA USACHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Friedman, Leah
Mulin, Emmanuel
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机构:CHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Mulin, Emmanuel
Noda, Art
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Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USACHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Noda, Art
Le Duff, Franck
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VA Palo Alto Hlth Care Syst, Psychiat Serv, Palo Alto, CA USACHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Le Duff, Franck
Kennedy, Quinn
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Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USACHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Kennedy, Quinn
Garcia, Rene
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Univ Nice Sophia Antipolis, Lab Neurobiol & Psychotraumatol, F-06002 Nice, FranceCHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Garcia, Rene
Robert, Philippe H.
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h-index: 0
机构:CHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Robert, Philippe H.
Yesavage, Jerome A.
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Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
VA Palo Alto Hlth Care Syst, Psychiat Serv, Palo Alto, CA USACHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Yesavage, Jerome A.
Zeitzer, Jamie M.
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Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
VA Palo Alto Hlth Care Syst, Psychiat Serv, Palo Alto, CA USACHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
机构:
Cent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Zhang, Feng
Liu, Xiaowei
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Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Liu, Xiaowei
Wang, Bailing
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h-index: 0
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Qingdao Mental Hlth Ctr, Qingdao, Shandong, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Wang, Bailing
Cheng, Zaohuo
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h-index: 0
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Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Cheng, Zaohuo
Zhao, Xingfu
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Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Zhao, Xingfu
Zhu, Jianzhong
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Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Zhu, Jianzhong
Wang, Degang
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Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Wang, Degang
Wang, Ying
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Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Wang, Ying
Dong, Aiguo
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Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Dong, Aiguo
Li, Pengpeng
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h-index: 0
机构:
Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
Li, Pengpeng
Jin, Chunhui
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h-index: 0
机构:
Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R ChinaCent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China
机构:
CHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USACHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
David, Renaud
Friedman, Leah
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h-index: 0
机构:
Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
VA Palo Alto Hlth Care Syst, Psychiat Serv, Palo Alto, CA USACHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Friedman, Leah
Mulin, Emmanuel
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h-index: 0
机构:CHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Mulin, Emmanuel
Noda, Art
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h-index: 0
机构:
Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USACHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Noda, Art
Le Duff, Franck
论文数: 0引用数: 0
h-index: 0
机构:
VA Palo Alto Hlth Care Syst, Psychiat Serv, Palo Alto, CA USACHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Le Duff, Franck
Kennedy, Quinn
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USACHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Kennedy, Quinn
Garcia, Rene
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nice Sophia Antipolis, Lab Neurobiol & Psychotraumatol, F-06002 Nice, FranceCHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Garcia, Rene
Robert, Philippe H.
论文数: 0引用数: 0
h-index: 0
机构:CHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Robert, Philippe H.
Yesavage, Jerome A.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
VA Palo Alto Hlth Care Syst, Psychiat Serv, Palo Alto, CA USACHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France
Yesavage, Jerome A.
Zeitzer, Jamie M.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
VA Palo Alto Hlth Care Syst, Psychiat Serv, Palo Alto, CA USACHU Univ Nice Sophia Antipolis, Hop Cimiez, Ctr Memoire Ressources Rech EA CoBTeK, F-06002 Nice, France