The concept of disease modification

被引：10

作者：

Cross, J. Helen ^{[1
]}

Lagae, Lieven ^{[2
]}

机构：

[1] UCL NIHR BRC Great Ormond St Inst Child Hlth, London WC1N 1EH, England

[2] Univ Hosp Leuven, Paediat Neurol, Herestr 49, B-3000 Leuven, BE, Belgium

来源：

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY | 2020年 / 24卷

关键词：

Disease modification; Epilepsy; Epileptic encephalopathy; ONSET; LAMOTRIGINE;

D O I：

10.1016/j.ejpn.2019.12.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Traditionally treatment of epileptic seizures has been symptomatic, namely medication has been targeted at raising the threshold to the occurrence of epileptic seizures. This has had little impact on the rate of drug resistance over time, or impact on comorbidities such as learning and behaviour particularly in the early onset epilepsies. The advent of advanced neuroimaging and genomics has revealed the cause of the epilepsy in a much higher percentage, and advanced our knowledge as to the underlying pathophysiology. This has given us the opportunity to turn to the possibility of interventional treatment, targeting the underlying cause, and consequently the possibility of changing the natural history of disease. Here we review the options open to us, and the evidence to date. (C) 2019 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：43 / 46

页数：4

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