Electroencephalography as a Non-Invasive Biomarker of Alzheimer's Disease: A Forgotten Candidate to Substitute CSF Molecules?

被引：27

作者：

Monllor, Paloma ^{[1
]}

Cervera-Ferri, Ana ^{[2
]}

Lloret, Maria-Angeles ^{[3
]}

Esteve, Daniel ^{[1
]}

Lopez, Begona ^{[4
]}

Leon, Jose-Luis ^{[5
]}

Lloret, Ana ^{[1
]}

机构：

[1] Hlth Res Univ Valencia, Inst INCLIVA, Dept Physiol, CIBERFES,Fac Med, Avda Blasco Ibanez 17, Valencia 46010, Spain

[2] Univ Valencia, Dept Human Anat & Embryol, Fac Med, Valencia 46010, Spain

[3] Univ Clin Hosp Valencia, Dept Clin Neurophysiol, Avda Blasco Ibanez 19, Valencia 46010, Spain

[4] Univ Clin Hosp Valencia, Dept Neurol, Avda Blasco Ibanez 19, Valencia 46010, Spain

[5] Hosp Clin Univ, Dept Neuroradiol, Ascires Biomed Grp, Valencia 46010, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 19期

关键词：

EEG; Alzheimer's disease diagnosis; non-invasive biomarkers; cerebral rhythms; alpha wave; synchrony; complexity; MILD COGNITIVE IMPAIRMENT; MUTUAL INFORMATION ANALYSIS; EEG BACKGROUND ACTIVITY; QUANTITATIVE EEG; CORTICAL SOURCES; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; APPROXIMATE ENTROPY; NATIONAL INSTITUTE; SENILE-DEMENTIA;

D O I：

10.3390/ijms221910889

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biomarkers for disease diagnosis and prognosis are crucial in clinical practice. They should be objective and quantifiable and respond to specific therapeutic interventions. Optimal biomarkers should reflect the underlying process (pathological or not), be reproducible, widely available, and allow measurements repeatedly over time. Ideally, biomarkers should also be non-invasive and cost-effective. This review aims to focus on the usefulness and limitations of electroencephalography (EEG) in the search for Alzheimer's disease (AD) biomarkers. The main aim of this article is to review the evolution of the most used biomarkers in AD and the need for new peripheral and, ideally, non-invasive biomarkers. The characteristics of the EEG as a possible source for biomarkers will be revised, highlighting its advantages compared to the molecular markers available so far.

引用

页数：22

共 146 条

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