Determinants of antibody response to severe acute respiratory syndrome coronavirus 2 mRNA vaccines in people with HIV

被引：11

作者：

Chammartin, Frederique ^{[1
]}

Kusejko, Katharina ^{[2
,3
,4
]}

Pasin, Chloe ^{[4
]}

Trkola, Alexandra ^{[4
]}

Briel, Matthias ^{[1
]}

Amico, Patrizia ^{[5
]}

Stoekle, Marcel P. ^{[6
]}

Eichenberger, Anna L. ^{[7
]}

Hasse, Barbara ^{[3
]}

Braun, Dominique L. ^{[4
]}

Schuurmans, Mace M. ^{[8
]}

Mueller, Thomas F.

Tamm, Michael ^{[10
]}

Mueller, Nicolas J. ^{[2
,3
,9
]}

Rauch, Andri

Koller, Michael T. ^{[11
,12
]}

Guenthard, Huldrych F. ^{[3
,4
]}

Bucher, Heiner C. ^{[1
]}

Speich, Benjamin ^{[1
]}

Abela, Irene A. ^{[2
,3
]}

机构：

[1] Univ Basel, Univ Basel Hosp, Basel Inst Clin Epidemiol & Biostat, Dept Clin Res, Spitalstr12, CH-4056 Basel, Switzerland

[2] Univ Hosp Zurich, Div Infect Dis, Zurich, Switzerland

[3] Univ Hosp Zurich, Hosp Epidemiol, Zurich, Switzerland

[4] Univ Zurich, Inst Med Virol, Zurich, Switzerland

[5] Univ Basel, Clin Transplantat Immunol & Nephrol, Basel, Switzerland

[6] Univ Basel, Univ Basel Hosp, Div Infectious Dis, Basel, Switzerland

[7] Univ Basel, Hosp Epidemiol, Basel, Switzerland

[8] Univ Bern, Univ Hosp Bern, Inselspital, Dept Infect Dis, Bern, Switzerland

[9] Univ Hosp Zurich, Div Pulmonol, Zurich, Switzerland

[10] Univ Hosp Zurich, Nephrol Clin, Zurich, Switzerland

[11] Univ Basel, Univ Basel Hosp, Clin Resp Med & Pulm Cell Res, Basel, Switzerland

[12] Univ Basel, Univ Basel Hosp, Swiss Transplant Cohort Study, Basel, Switzerland

来源：

AIDS | 2022年 / 36卷 / 10期

基金：

瑞士国家科学基金会;

关键词：

VACCINATION; SARS-COV-2; SAFETY;

D O I：

10.1097/QAD.0000000000003246

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We identified determinants of SARS-CoV-2 mRNA vaccine antibody response in people with HIV (PWH). Antibody response was higher among PWH less than 60 years, with CD4(+) cell count superior to 350 cells/mu l and vaccinated with mRNA-1273 by Moderna compared with BNT162b2 by Pfizer-BioNTech. Preinfection with SARS-CoV-2 boosted the antibody response and smokers had an overall lower antibody response. Elderly PWH and those with low CD4(+) cell count should be prioritized for booster vaccinations.

引用

页码：1465 / 1468

页数：4

共 23 条

[1]

Abela Irene A, 2021, Nat Commun, V12, P1

[2] Effect of mRNA Vaccine Boosters against SARS-CoV-2 Omicron Infection in Qatar [J].

Abu-Raddad, L. J. ;

Chemaitelly, H. ;

Ayoub, H. H. ;

AlMukdad, S. ;

Yassine, H. M. ;

Al-Khatib, H. A. ;

Smatti, M. K. ;

Tang, P. ;

Hasan, M. R. ;

Coyle, P. ;

Al-Kanaani, Z. ;

Al-Kuwari, E. ;

Jeremijenko, A. ;

Kaleeckal, A. H. ;

Latif, A. N. ;

Shaik, R. M. ;

Abdul-Rahim, H. F. ;

Nasrallah, G. K. ;

Al-Kuwari, M. G. ;

Butt, A. A. ;

Al-Romaihi, H. E. ;

Al-Thani, M. H. ;

Al-Khal, A. ;

Bertollini, R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (19) :1804-1816

[3] SARS-CoV-2 Antibody Responses in Infection-Naive or Previously Infected Individuals After 1 and 2 Doses of the BNT162b2 Vaccine [J].

Anderson, Mark ;

Stec, Michael ;

Rewane, Ayesan ;

Landay, Alan ;

Cloherty, Gavin ;

Moy, James .

JAMA NETWORK OPEN, 2021, 4 (08)

[4] Three doses of BNT162b2 vaccine confer neutralising antibody capacity against the SARS-CoV-2 Omicron variant [J].

Arien, Kevin K. ;

Heyndrickx, Leo ;

Michiels, Johan ;

Vereecken, Katleen ;

Van Lent, Kurt ;

Coppens, Sandra ;

Willems, Betty ;

Pannus, Pieter ;

Martens, Geert A. ;

Van Esbroeck, Marjan ;

Goossens, Maria E. ;

Marchant, Arnaud ;

Bartholomeeusen, Koen ;

Desombere, Isabelle .

NPJ VACCINES, 2022, 7 (01)

[5]

Brumme Zabrina L, 2021, medRxiv, DOI 10.1101/2021.10.03.21264320

[6] Incidence and Severity of COVID-19 in HIV-Positive Persons Receiving Antiretroviral Therapy A Cohort Study [J].

del Amo, Julia ;

Polo, Rosa ;

Moreno, Santiago ;

Diaz, Asuncion ;

Martinez, Esteban ;

Ramon Arribas, Jose ;

Jarrin, Inma ;

Hernan, Miguel A. .

ANNALS OF INTERNAL MEDICINE, 2020, 173 (07) :536-+

[7] The Effect of Smoking on Humoral Response to COVID-19 Vaccines: A Systematic Review of Epidemiological Studies [J].

Ferrara, Pietro ;

Gianfredi, Vincenza ;

Tomaselli, Venera ;

Polosa, Riccardo .

VACCINES, 2022, 10 (02)

[8] Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine [J].

Frasca, Daniela ;

Diaz, Alain ;

Romero, Maria ;

Landin, Ana Marie ;

Blomberg, Bonnie B. .

VACCINE, 2015, 33 (12) :1433-1439

[9] Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in HIV infection: a single-arm substudy of a phase 2/3 clinical trial [J].

Frater, John ;

Ewer, Katie J. ;

Ogbe, Ane ;

Pace, Mathew ;

Adele, Sandra ;

Adland, Emily ;

Alagaratnam, Jasmini ;

Aley, Parvinder K. ;

Ali, Mohammad ;

Ansari, M. Azim ;

Bara, Anna ;

Bittaye, Mustapha ;

Broadhead, Samantha ;

Brown, Anthony ;

Brown, Helen ;

Cappuccini, Federica ;

Cooney, Enya ;

Dejnirattisai, Wanwisa ;

Dold, Christina ;

Fairhead, Cassandra ;

Fok, Henry ;

Folegatti, Pedro M. ;

Fowler, Jamie ;

Gibbs, Charlotte ;

Goodman, Anna L. ;

Jenkin, Daniel ;

Jones, Mathew ;

Makinson, Rebecca ;

Marchevsky, Natalie G. ;

Mujadidi, Yama F. ;

Nguyen, Hanna ;

Parolini, Lucia ;

Petersen, Claire ;

Plested, Emma ;

Pollock, Katrina M. ;

Ramasamy, Maheshi N. ;

Rhead, Sarah ;

Robinson, Hannah ;

Robinson, Nicola ;

Rongkard, Patpong ;

Ryan, Fiona ;

Serrano, Sonia ;

Tipoe, Timothy ;

Voysey, Merryn ;

Waters, Anele ;

Zacharopoulou, Panagiota ;

Barnes, Eleanor ;

Dunachie, Susanna ;

Goulder, Philip ;

Klenerman, Paul .

LANCET HIV, 2021, 8 (08) :E474-E485

[10] Three Doses of an mRNA Covid-19 Vaccine in Solid-Organ Transplant Recipients [J].

Kamar, Nassim ;

Abravanel, Florence ;

Marion, Olivier ;

Couat, Chloe ;

Izopet, Jacques ;

Del Bello, Arnaud .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (07) :661-662

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