Bioactive 1,1′-unsymmetrical bi-functional ferrocenyl compounds using a novel solvent free one pot multicomponent reaction method

被引：13

作者：

Barik, Tulasi ^{[1
]}

Ghosh, Avishek ^{[1
]}

Mishra, Abtar ^{[2
]}

Dhiman, Rohan ^{[2
]}

Sasamori, Takahiro ^{[3
]}

Chatterjee, Saurav ^{[1
]}

机构：

[1] Natl Inst Technol Rourkela, Dept Chem, Rourkela 769008, Odisha, India

[2] Natl Inst Technol Rourkela, Dept Life Sci, Rourkela 769008, Odisha, India

[3] Nagoya City Univ, Grad Sch Nat Sci, Nagoya, Aichi 4678501, Japan

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2020年 / 908卷

关键词：

Solvent free; Anticancer; Ferrocenyl; Unsymmetrical; Rice husk ash; RAPID COLORIMETRIC ASSAY; KNOEVENAGEL CONDENSATION; SELECTIVE REDUCTION; DIPEPTIDE CHAINS; METAL-COMPLEXES; SERUM-ALBUMIN; THIOSEMICARBAZONES; ANTIBACTERIAL; ALDEHYDES; IRON;

D O I：

10.1016/j.jorganchem.2019.121095

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A solvent free synthetic method using rice husk ash (RHA) as solid support has been designed for selective functionalization and preparation of novel 1,1'- unsymmetrically bi-functionalized ferrocenyl compounds. The selectively functionalized intermediate compound, Ferrocenyl-1-acetyl-1'-thiosemicarbazone, has been structurally characterized using single crystal X-ray diffraction technique which revealed distinct inter-molecular hydrogen bonding interactions across the thiosemicarbazone chains. Cytotoxic evaluation of five different unsymmetrically bi-functionalized thiosemicarbazone - hydrazone compounds showed potent activity against human leukemia (THP-1) cell line. The unsymmetrical ferrocenyl compounds also showed strong BSA and DNA binding interactions and reversible redox properties. (C) 2019 Elsevier B.V. All rights reserved.

引用

页数：11

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