Hypothyroidism and Its Association With Sleep Apnea Among Adults in the United States: NHANES 2007-2008

被引:36
作者
Thavaraputta, Subhanudh [1 ]
Dennis, Jeff A. [2 ]
Laoveeravat, Passisd [1 ]
Nugent, Kenneth [3 ]
Rivas, Ana M. [4 ]
机构
[1] Texas Tech Univ, Hlth Sci Ctr, Dept Internal Med, Lubbock, TX 79430 USA
[2] Texas Tech Univ, Hlth Sci Ctr, Dept Publ Hlth, Lubbock, TX 79430 USA
[3] Texas Tech Univ, Hlth Sci Ctr, Dept Internal Med, Div Pulmonol & Crit Care, Lubbock, TX 79430 USA
[4] Texas Tech Univ, Hlth Sci Ctr, Dept Internal Med, Div Endocrinol, Lubbock, TX 79430 USA
关键词
AMERICAN THYROID ASSOCIATION; PREVALENCE; GUIDELINES; POPULATION; MANAGEMENT; MECHANISMS; DIAGNOSIS; DISEASE; TSH;
D O I
10.1210/jc.2019-01132
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Context: The association between hypothyroidism and sleep apnea (SA) has been studied, but results are conflicting and based mostly on small studies. Objective: To determine whether there is a positive association between hypothyroidism and SA in the US population. Design: Cross-sectional study. Setting: US National Health and Nutrition Examination Survey, 2007-2008. Participants: We included all subjects >= 18 years old who met inclusion criteria. Participants not on antithyroid medication with a TSH >5.6 mIU/L and those on thyroid hormone replacement regardless of TSH were categorized as hypothyroid. Participants not on thyroid hormone replacement or antithyroid medication who had a TSH >= 34 and <= 5.6 mIU/L were categorized as euthyroid. The diagnosis of SA was based on participants' response when asked whether they had been diagnosed with SA by their doctors. Main Outcome Measures: Multivariate logistic regression analyses were performed to determine the association between hypothyroidism and SA. Results: A total of 5515 adults were included for data analysis. The prevalence of hypothyroidism and hyperthyroidism was calculated at 9.47% and 1.19%, respectively. Multivariate logistic regression analysis adjusted for demographics, health care access, body mass index, socioeconomic factors, alcohol use, smoking, and other comorbidities demonstrated a significant association between hypothyroidism and SA (OR = 1.88, 95% CI, 1.24 to 2.84, P < 0.01). Conclusion: Hypothyroidism is associated with SA after adjustment for potential confounding variables.
引用
收藏
页码:4990 / 4997
页数:8
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