Chain migration of neuronal precursors

被引:1039
作者
Lois, C
GarciaVerdugo, JM
AlvarezBuylla, A
机构
[1] ROCKEFELLER UNIV,NEW YORK,NY 10021
[2] UNIV VALENCIA,FAC BIOL,E-46100 VALENCIA,SPAIN
关键词
D O I
10.1126/science.271.5251.978
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In the brain of adult mice, cells that divide in the subventricular zone of the lateral ventricle migrate up to 5 millimeters to the olfactory bulb where they differentiate into neurons. These migrating cells were found to move as chains through a well-defined pathway, the rostral migratory stream. Electron microscopic analysis of serial sections showed that these chains contained only closely apposed, elongated neuroblasts connected by membrane specializations. A second cell type, which contained glial fibrillary acidic protein, ensheathed the chains of migrating neuroblasts. Thus, during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.
引用
收藏
页码:978 / 981
页数:4
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