Palladium-Catalyzed Sequential Nucleophilic Addition/Oxidative Annulation of Bromoalkynes with Benzoic Acids To Construct Functionalized Isocoumarins

被引：71
作者：
Jiang, Guangbin [1 ]
Li, JianXiao [1 ]
Zhu, Chuanle [1 ]
Wu, Wanqing [1 ]
Jiang, Huanfeng [1 ]
机构：
[1] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 17期
基金：
中国国家自然科学基金;
关键词：
HYDRANGEAE-DULCIS FOLIUM; ONE-STEP SYNTHESIS; ONE-POT SYNTHESIS; ALPHA-KETO ACIDS; STEREOSELECTIVE-SYNTHESIS; ALKYNYL HALIDES; DECARBONYLATIVE ADDITION; THUNBERGINOL-B; DERIVATIVES; HALOALKYNES;
D O I：
10.1021/acs.orglett.7b01919
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and robust protocol for the preparation of 3-substituted isocoumarins via palladium-catalyzed nucleophilic addition/oxidative annulation of bromoalkynes with benzoic acids has been developed. Remarkably, preliminary mechanistic studies indicated that the transformation might proceed via a stereo- and regioselective nucleophilic addition and C-H functionalization procedure.
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收藏
页码：4440 / 4443
页数：4
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