Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents

被引：11

作者：

Asrorov, Akmal M. ^{[1
,2
,3
]}

Muhitdinov, Bahtiyor ^{[1
,2
]}

Tu, Bin ^{[1
]}

Mirzaakhmedov, Sharafitdin ^{[2
]}

Wang, Huiyuan ^{[1
]}

Huang, Yongzhuo ^{[1
,4
,5
,6
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[2] Uzbek Acad Sci, Inst Bioorgan Chem, Tashkent 100125, Uzbekistan

[3] Ajou Univ Tashkent, Sci Dept, Tashkent 100204, Uzbekistan

[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[5] Chinese Acad Sci, Zhongshan Inst Drug Discovery, Zhongshan 528437, Peoples R China

[6] Natl Med Prod Adm, Key Lab Qual Res & Evaluat Pharmaceut Excipients, Shanghai 201203, Peoples R China

来源：

MOLECULES | 2022年 / 27卷 / 12期

关键词：

enzyme drugs; cancer therapy; trichosanthin; gelonin; peroxidase; glucose oxidase; asparaginase; exotoxin; diphtheria toxin; PHASE-I TRIAL; IMMUNOTOXIN RFB4(DSFV)-PE38 BL22; RIBOSOME-INACTIVATING PROTEIN; TARGETED PSEUDOMONAS EXOTOXIN; ADVANCED SOLID TUMORS; PTD-MODIFIED ATTEMPTS; GROWTH-FACTOR ALPHA; DIPHTHERIA-TOXIN; L-ASPARAGINASE; GLUCOSE-OXIDASE;

D O I：

10.3390/molecules27123836

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer is one of the most serious human diseases, causing millions of deaths worldwide annually, and, therefore, it is one of the most investigated research disciplines. Developing efficient anticancer tools includes studying the effects of different natural enzymes of plant and microbial origin on tumor cells. The development of various smart delivery systems based on enzyme drugs has been conducted for more than two decades. Some of these delivery systems have been developed to the point that they have reached clinical stages, and a few have even found application in selected cancer treatments. Various biological, chemical, and physical approaches have been utilized to enhance their efficiencies by improving their delivery and targeting. In this paper, we review advanced delivery systems for enzyme drugs for use in cancer therapy. Their structure-based functions, mechanisms of action, fused forms with other peptides in terms of targeting and penetration, and other main results from in vivo and clinical studies of these advanced delivery systems are highlighted.

引用

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