A Review of ex vivo Elemental Mapping Methods to Directly Image Changes in the Homeostasis of Diffusible Ions (Na+, K+, Mg2+, Ca2+, Cl-) Within Brain Tissue

被引：12

作者：

Hartnell, David ^{[1
,2
,3
]}

Andrews, Wendy ^{[1
,2
,3
]}

Smith, Nicole ^{[4
]}

Jiang, Haibo ^{[4
]}

McAllum, Erin ^{[5
]}

Rajan, Ramesh ^{[6
]}

Colbourne, Frederick ^{[7
,8
,9
]}

Fitzgerald, Melinda ^{[2
,10
,11
]}

Lam, Virginie ^{[2
,12
]}

Takechi, Ryusuke ^{[2
,12
]}

Pushie, M. Jake ^{[13
]}

Kelly, Michael E. ^{[13
]}

Hackett, Mark J. ^{[1
,2
,3
]}

机构：

[1] Curtin Univ, Fac Sci & Engn, Sch Mol & Life Sci, Perth, WA, Australia

[2] Curtin Univ, Curtin Hlth Innovat Res Inst, Perth, WA, Australia

[3] Curtin Univ, Curtin Inst Funct Mol & Interfaces, Perth, WA, Australia

[4] Univ Western Australia, Fac Sci, Sch Mol Sci, Perth, WA, Australia

[5] Florey Inst Neurosci & Mental Hlth, Melbourne Dementia Res Ctr, Parkville, Vic, Australia

[6] Monash Univ, Biomed Discovery Inst, Clayton, Vic, Australia

[7] Univ Alberta, Dept Neurosci, Edmonton, AB, Canada

[8] Univ Alberta, Mental Hlth Inst, Edmonton, AB, Canada

[9] Univ Alberta, Fac Arts, Dept Psychol, Edmonton, AB, Canada

[10] Univ Western Australia, Sch Biol Sci, Perth, WA, Australia

[11] Perron Inst Neurol & Translat Sci, Perth, WA, Australia

[12] Curtin Univ, Fac Hlth Sci, Sch Publ Hlth, Perth, WA, Australia

[13] Univ Saskatchewan, Coll Med, Dept Surg, Saskatoon, SK, Canada

来源：

FRONTIERS IN NEUROSCIENCE | 2020年 / 13卷

基金：

澳大利亚研究理事会;

关键词：

ischemia; metabolism; imaging; XFM; SIMS; LA-ICP-MS; PIXE; microprobe; PLASMA-MASS SPECTROMETRY; CHOROID-PLEXUS CALCIFICATION; LA-ICP-MS; LASER-ABLATION; HIPPOCAMPAL-FORMATION; SPREADING DEPRESSION; RAT HIPPOCAMPUS; HIGH-RESOLUTION; TRACE-ELEMENTS; WHITE-MATTER;

D O I：

10.3389/fnins.2019.01415

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Diffusible ions (Na+, K+, Mg2+, Ca2+, Cl-) are vital for healthy function of all cells, especially brain cells. Unfortunately, the diffusible nature of these ions renders them difficult to study with traditional microscopy in situ within ex vivo brain tissue sections. This mini-review examines the recent progress in the field, using direct elemental mapping techniques to study ion homeostasis during normal brain physiology and pathophysiology, through measurement of ion distribution and concentration in ex vivo brain tissue sections. The mini-review examines the advantages and limitations of specific techniques: proton induced X-ray emission (PIXE), X-ray fluorescence microscopy (XFM), secondary ion mass spectrometry (SIMS), laser-ablation inductively coupled plasma mass spectrometry (LA-ICP-MS), and the sample preparation requirements to study diffusible ions with these methods.

引用

页数：8

共 69 条

[1] Astrocyte-endothelial interactions at the blood-brain barrier [J].

Abbott, NJ ;

Rönnbäck, L ;

Hansson, E .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (01) :41-53

[2]

BACHELARD H, 1993, J NEUROCHEM, V61, P412

[3] Bioimaging mass spectrometry of trace elements - recent advance and applications of LA-ICP-MS: A review [J].

Becker, J. Sabine ;

Matusch, Andreas ;

Wu, Bei .

ANALYTICA CHIMICA ACTA, 2014, 835 :1-18

[4] Choroid plexus calcification as a possible clue of serotonin implication in schizophrenia [J].

Bersani, G ;

Garavini, A ;

Taddei, I ;

Tanfani, G ;

Pancheri, P .

NEUROSCIENCE LETTERS, 1999, 259 (03) :169-172

[5] A guide to integrating immunohistochemistry and chemical imaging [J].

Bishop, David P. ;

Cole, Nerida ;

Zhang, Tracy ;

Doble, Philip A. ;

Hare, Dominic J. .

CHEMICAL SOCIETY REVIEWS, 2018, 47 (11) :3770-3787

[6] A novel multi-modal platform to image molecular and elemental alterations in ischemic stroke [J].

Caine, Sally ;

Hackett, Mark J. ;

Hou, Huishu ;

Kumar, Saroj ;

Maley, Jason ;

Ivanishvili, Zurab ;

Suen, Brandon ;

Szmigielski, Aleksander ;

Jiang, Zhongxiang ;

Sylvain, Nicole J. ;

Nichol, Helen ;

Kelly, Michael E. .

NEUROBIOLOGY OF DISEASE, 2016, 91 :132-142

[7] Subcellular imaging by dynamic SIMS ion microscopy [J].

Chandra, S ;

Smith, DR ;

Morrison, GH .

ANALYTICAL CHEMISTRY, 2000, 72 (03) :104A-114A

[8] Quantitative imaging of magnesium distribution at single-cell resolution in brain tumors and infiltrating tumor cells with secondary ion mass spectrometry (SIMS) [J].

Chandra, Subhash ;

Parker, Dylan J. ;

Barth, Rolf F. ;

Pannullo, Susan C. .

JOURNAL OF NEURO-ONCOLOGY, 2016, 127 (01) :33-41

[9] Preparation of tissue samples for X-ray fluorescence microscopy [J].

Chwiej, J ;

Szczerbowska-Boruchowska, M ;

Lankosz, M ;

Wojcik, S ;

Falkenberg, G ;

Stegowski, Z ;

Setkowicz, Z .

SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY, 2005, 60 (12) :1531-1537

[10] Progress of elemental anomalies of hippocampal formation in the pilocarpine model of temporal lobe epilepsy-an X-ray fluorescence microscopy study [J].

Chwiej, J. ;

Kutorasinska, J. ;

Janeczko, K. ;

Gzielo-Jurek, K. ;

Uram, L. ;

Appel, K. ;

Simon, R. ;

Setkowicz, Z. .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2012, 404 (10) :3071-3080

← 1 2 3 4 5 6 7 →