Carbon Helical Nanorobots Capable of Cell Membrane Penetration for Single Cell Targeted SERS Bio-Sensing and Photothermal Cancer Therapy

被引:67
作者
Chen, Yuduo [1 ,2 ]
Pan, Renjie [3 ]
Wang, Yong [1 ,2 ]
Guo, Peiting [1 ,2 ]
Liu, Xiaojia [1 ,2 ]
Ji, Fengtong [4 ]
Hu, Jing [5 ]
Yan, Xiaohui [5 ]
Wang, Guo Ping [3 ,6 ]
Zhang, Li [4 ]
Sun, Yanming [3 ,6 ]
Ma, Xing [1 ,2 ]
机构
[1] Harbin Inst Technol Shenzhen, Sauvage Lab Smart Mat, Shenzhen 518055, Peoples R China
[2] Harbin Inst Technol Shenzhen, Sch Mat Sci & Engn, Shenzhen 518055, Peoples R China
[3] Shenzhen Univ, Coll Elect & Informat Engn, 3688 Nanhai Blvd, Shenzhen 518060, Peoples R China
[4] Chinese Univ Hong Kong, Dept Mech & Automat Engn, Shatin, Hong Kong, Peoples R China
[5] Xiamen Univ, State Key Lab Mol Vaccinol & Mol Diagnost, Ctr Mol Imaging & Translat Med, Sch Publ Hlth, Xiamen 361005, Peoples R China
[6] Shenzhen Univ, Inst Microscale Optoelect, 3688 Nanhai Blvd, Shenzhen 518060, Peoples R China
基金
中国国家自然科学基金;
关键词
helical structures; magnetic micro; nano-robots; membrane penetration; single cell targets; surface enhanced Raman scattering; INTRACELLULAR DELIVERY; RAMAN-SPECTROSCOPY; RECENT PROGRESS; DRUG-DELIVERY; ELECTROPORATION; FABRICATION; NANOMOTORS; BACTERIA; GROWTH; CARGO;
D O I
10.1002/adfm.202200600
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Penetration of cell membrane at micro/nano-scale with untethered probe is of great scientific significance, yet still challenging. Here, a carbon nanocoil based magnetic nanorobot, which can precisely target single cell and perform cell membrane penetration, is reported. The nanorobots are as-synthesized by chemical vapor deposition with high yield, followed by physical deposition of Ni and Au nanofilms. Rotating electromagnetic fields are used to steer the nanorobots to navigate following any pre-designed path. The helical nanorobots can realize mechanical perforation of the plasma membrane and even nuclear envelope with precise position at the subcellular level. With the aid of the externally deposited Au nanofilm, surface enhanced Raman scattering bio-sensing signals can be collected from cellular plasma and nucleus. Furthermore, the nanorobots demonstrate capability of efficient photothermal therapy against targeted cancer cells and serve as an integrated theranostic platform, providing promising prospects in future precision medicine.
引用
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页数:10
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