Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3)

被引：47
作者：
Kaptein, A
Jansen, M
Dilaver, G
Kitson, J
Dash, L
Wang, E
Owen, MJ
Bodmer, JL
Tschopp, J
Farrow, SN
机构：
[1] Univ Lausanne, Inst Biochem, CH-1066 Epalinges, Switzerland
[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Dept Cell Biol, Stevenage SG1 2NY, Herts, England
[3] Imperial Canc Res Fund, London WC2A 3PX, England
来源：
FEBS LETTERS | 2000年 / 485卷 / 2-3期
关键词：
TWEAK; WSL-1; TRAMP; death receptor; apoptosis;
D O I：
10.1016/S0014-5793(00)02219-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
WSL-1/TRAMP (DR3) is a member of the tumour necrosis factor (TNF) receptor superfamily which exhibits effects on NF-kappaB activation and apoptosis, TWEAK, a novel TNF-related molecule, has been proposed as the ligand for this receptor. Utilising both human and murine TWEAK ligand, it is shown that TWEAK and WSL-1/TRAMP do not interact in an in vitro binding assay and that TWEAK binds strongly to cells that do not express WSL-1/TRAMP on the cell surface. Biological activity of TWEAK is also observed in these cells. Finally, cells isolated from WSL-1/TRAMP knockout mice are shown to retain their ability to interact with TWEAK. These results suggest that WSL-1/TRAMP is not the major receptor for TWEAK (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码：135 / 141
页数：7
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