Development and pharmacokinetics evaluation of quetiapine fumarate sustained-release tablets based on hydrophilic matrix

被引：7
作者：
Zhang, Xuejuan [1 ,2 ]
Li, Yongcheng [3 ]
Huang, Zhengwei [2 ]
Cui, Yingtong [2 ]
Zhao, Ziyu [2 ,4 ]
Yue, Xiao [2 ]
Wang, Guanlin [2 ]
Liang, Ruifeng [2 ]
Huang, Ying [2 ]
Tan, Wen [1 ]
Wu, Chuanbin [2 ]
机构：
[1] Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
[3] Guangdong PD Pharmaceut Co Ltd, Guangzhou 510006, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Pharmacol, Guangzhou 510080, Guangdong, Peoples R China
来源：
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2019年 / 54卷
基金：
美国国家科学基金会;
关键词：
Quetiapine fumarate; Sustained release; Hydrophilic matrix; Tablet; Blend polymer system; BIPOLAR DISORDER; DOUBLE-BLIND; IN-VITRO; DRUG-RELEASE; DELIVERY-SYSTEMS; HYDROGEL MATRIX; HPMC; BEHAVIOR; NANOPARTICLES; MONOTHERAPY;
D O I：
10.1016/j.jddst.2019.101322
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Formulation with sustained release profiles is highly desired for the treatment of bipolar disorder (BD) to improve patient compliance by avoiding frequent dosing and stabilizing drug plasma concentration. For this purpose, quetiapine fumarate hydrophilic matrix tablets (QFHMTs) was designed and developed in this study. This hydrophilic matrix was accomplished by the blended polymer systems composed of HPMC K100LV and HPMC K4M to achieve appropriate hydration rate and gel strength for sustained-release of QF. QFHMTs was optimized by single factor experiment and orthogonal test, and the reproducibility test was confirmed. The optimized QFHMTs showed 24-h sustained release profile. Moreover, the results of stress testing, accelerated and long-term testing manifested its excellent storage stability with an Opadry200 coat. QFHMTs was proved promising for the treatment of BD.
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页数：9
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