Secreted aspartyl proteinases and interactions of Candida albicans with human endothelial cells

被引：54
作者：
Ibrahim, AS
Filler, SG
Sanglard, D
Edwards, JE
Hube, B
机构：
[1] Univ Calif Los Angeles, Harbor Med Ctr, Div Infect Dis,Res & Educ Inst, St Johns Cardiovasc Res Ctr,Dept Med, Torrance, CA 90509 USA
[2] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90024 USA
[3] CHU Vaudois, Inst Microbiol, CH-1011 Lausanne, Switzerland
[4] Univ Hamburg, Inst Allgemeine Bot, AMP 3, D-22609 Hamburg, Germany
来源：
INFECTION AND IMMUNITY | 1998年 / 66卷 / 06期
关键词：
D O I：
10.1128/IAI.66.6.3003-3005.1998
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The endothelial cell interactions of homozygous null mutants of Candida albicans that were deficient in secreted aspartyl proteinase 1 (Sap1), Sap2, or Sap3 were investigated. Only Sap2 was found to contribute to the ability of C. albicans to damage endothelial cells and stimulate them to express E-selectin. None of the Saps studied appears to play a role in C. albicans adherence to endothelial cells.
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收藏
页码：3003 / 3005
页数：3
相关论文
共 15 条
  • [1] EXPRESSION OF EXTRACELLULAR ACID PROTEINASE BY PROTEOLYTIC CANDIDA SPP DURING EXPERIMENTAL-INFECTION OF ORAL-MUCOSA
    BORG, M
    RUCHEL, R
    [J]. INFECTION AND IMMUNITY, 1988, 56 (03) : 626 - 631
  • [2] CHARACTERIZATION OF CANDIDA-ALBICANS EPIDERMOLYTIC PROTEASES AND THEIR ROLE IN YEAST-CELL ADHERENCE TO KERATINOCYTES
    ELMAGHRABI, EA
    DIXON, DM
    BURNETT, JW
    [J]. CLINICAL AND EXPERIMENTAL DERMATOLOGY, 1990, 15 (03) : 183 - 191
  • [3] PENETRATION AND DAMAGE OF ENDOTHELIAL-CELLS BY CANDIDA-ALBICANS
    FILLER, SG
    SWERDLOFF, JN
    HOBBS, C
    LUCKETT, PM
    [J]. INFECTION AND IMMUNITY, 1995, 63 (03) : 976 - 983
  • [4] Candida albicans stimulates cytokine production and leukocyte adhesion molecule expression by endothelial cells
    Filler, SG
    Pfunder, AS
    Spellberg, BJ
    Spellberg, JP
    Edwards, JE
    [J]. INFECTION AND IMMUNITY, 1996, 64 (07) : 2609 - 2617
  • [5] HILENSKI LL, 1986, J GEN MICROBIOL, V132, P1441
  • [6] Hube B, 1996, Curr Top Med Mycol, V7, P55
  • [7] Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence
    Hube, B
    Sanglard, D
    Odds, FC
    Hess, D
    Monod, M
    Schafer, W
    Brown, AJP
    Gow, NAR
    [J]. INFECTION AND IMMUNITY, 1997, 65 (09) : 3529 - 3538
  • [8] EVIDENCE IMPLICATING PHOSPHOLIPASE AS A VIRULENCE FACTOR OF CANDIDA-ALBICANS
    IBRAHIM, AS
    MIRBOD, F
    FILLER, SG
    BANNO, Y
    COLE, GT
    KITAJIMA, Y
    EDWARDS, JE
    NOZAWA, Y
    GHANNOUM, MA
    [J]. INFECTION AND IMMUNITY, 1995, 63 (05) : 1993 - 1998
  • [9] INTERFERON-GAMMA PROTECTS ENDOTHELIAL-CELLS FROM DAMAGE BY CANDIDA-ALBICANS
    IBRAHIM, AS
    FILLER, SG
    GHANNOUM, MA
    EDWARDS, JE
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (06) : 1467 - 1470
  • [10] ADHERENCE OF CANDIDA-ALBICANS TO ENDOTHELIAL-CELLS IS INHIBITED BY PROSTAGLANDIN I-2
    KLOTZ, SA
    [J]. INFECTION AND IMMUNITY, 1994, 62 (04) : 1497 - 1500
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