Programmed cell death protein 4 (pdcd4):: A novel target for antineoplastic therapy?

被引：80

作者：

Lankat-Buttgereit, B ^{[1
]}

Göke, R ^{[1
]}

机构：

[1] Univ Marburg, Clin Res Unit Gastrointestinal Endocrinol, D-35037 Marburg, Germany

来源：

BIOLOGY OF THE CELL | 2003年 / 95卷 / 08期

关键词：

tumor suppressor; translation; apoptosis; eIF4A;

D O I：

10.1016/j.biolcel.2003.09.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pdcd4 is a novel gene first identified as a differentially expressed protein during apoptosis. In the meantime not only the impact of Pdcd4 in programmed cell death but also an implication in transformation suppression by inhibition of protein translation is discussed. These features implicate a potential value of Pdcd4 as a molecular target in cancer therapy. This review summarizes the current knowledge about expression, structure and function of Pdcd4. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：515 / 519

页数：5

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