Programmed cell death protein 4 (pdcd4):: A novel target for antineoplastic therapy?

被引：82

作者：

Lankat-Buttgereit, B ^{[1
]}

Göke, R ^{[1
]}

机构：

[1] Univ Marburg, Clin Res Unit Gastrointestinal Endocrinol, D-35037 Marburg, Germany

来源：

BIOLOGY OF THE CELL | 2003年 / 95卷 / 08期

关键词：

tumor suppressor; translation; apoptosis; eIF4A;

D O I：

10.1016/j.biolcel.2003.09.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pdcd4 is a novel gene first identified as a differentially expressed protein during apoptosis. In the meantime not only the impact of Pdcd4 in programmed cell death but also an implication in transformation suppression by inhibition of protein translation is discussed. These features implicate a potential value of Pdcd4 as a molecular target in cancer therapy. This review summarizes the current knowledge about expression, structure and function of Pdcd4. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：515 / 519

页数：5

共 38 条

[1] Targeted disruption of c-myb in the chicken pre B-cell line DT40 [J].

Appl, H ;

Klempnauer, KH .

ONCOGENE, 2002, 21 (19) :3076-3081

[2] Death receptors: Signaling and modulation [J].

Ashkenazi, A ;

Dixit, VM .

SCIENCE, 1998, 281 (5381) :1305-1308

[3]

Azzoni L, 1998, J IMMUNOL, V161, P3493

[4] A signaling pathway to translational control [J].

Brown, EJ ;

Schreiber, SL .

CELL, 1996, 86 (04) :517-520

[5] Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation [J].

Cmarik, JL ;

Min, HZ ;

Hegamyer, G ;

Zhan, SN ;

Kulesz-Martin, M ;

Yoshinaga, H ;

Matsuhashi, S ;

Colburn, NH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (24) :14037-14042

[6] DISSOCIATION OF MITOGENESIS AND LATE-STAGE PROMOTION OF TUMOR-CELL PHENOTYPE BY PHORBOL ESTERS - MITOGEN-RESISTANT VARIANTS ARE SENSITIVE TO PROMOTION [J].

COLBURN, NH ;

WENDEL, EJ ;

ABRUZZO, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :6912-6916

[7] TUMOR PROMOTER INDUCES ANCHORAGE INDEPENDENCE IRREVERSIBLY [J].

COLBURN, NH ;

FORMER, BF ;

NELSON, KA ;

YUSPA, SH .

NATURE, 1979, 281 (5732) :589-591

[8] A matter of life and cell death [J].

Evan, G ;

Littlewood, T .

SCIENCE, 1998, 281 (5381) :1317-1322

[9]

FukuchiShimogori T, 1997, CANCER RES, V57, P5041

[10] DUG is a novel homologue of translation initiation factor 4G that binds eIF4A [J].

Göke, A ;

Göke, R ;

Knolle, A ;

Trusheim, H ;

Schmidt, H ;

Wilmen, A ;

Carmody, R ;

Göke, B ;

Chen, YHH .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 297 (01) :78-82

← 1 2 3 4 →