Synthesis and in Vitro Photodynamic Activities of Pegylated Distyryl Boron Dipyrromethene Derivatives

被引：63

作者：

He, Hui ^{[1
]}

Lo, Pui-Chi ^{[1
]}

Yeung, Sin-Lui ^{[2
]}

Fong, Wing-Ping ^{[2
]}

Ng, Dennis K. P. ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Sch Life Sci, Shatin, Hong Kong, Peoples R China

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 54卷 / 08期

关键词：

EFFICIENT PHOTOSENSITIZERS; HIGHLY EFFICIENT; LOCALIZATION; SERIES; LOGIC;

D O I：

10.1021/jm101637g

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of pegylated distyryl boron dipyrromethenes have been prepared and characterized. Their in vitro photodynamic activities in Tween 80 emulsions have also been investigated against HT29 human colorectal carcinoma cells. The derivative having five triethylene glycol chains (compound 8) exhibits the highest. photocytotoxicity with an IC50 as low as 7 nM. It is also localized preferentially in the endoplasmic reticulum of the cells and can induce predominately apoptosis upon illumination.

引用

页码：3097 / 3102

页数：6

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