Phenotyping cardiomyopathy in adult zebrafish

被引：28

作者：

Dvornikov, Alexey V. ^{[1
]}

de Tombe, Pieter P. ^{[2
,3
,4
,5
]}

Xu, Xiaolei ^{[1
]}

机构：

[1] Mayo Clin, Dept Cardiovasc Med, Dept Biochem & Mol Biol, 200 1st St SW, Rochester, MN 55905 USA

[2] Univ Illinois, Dept Physiol & Biophys, Chicago, IL 60680 USA

[3] Magdi Yacoub Inst, Cardiac Biophys Div, Harefield, Middx, England

[4] Imperial Coll, Heart & Lung Inst, London, England

[5] Freiberg Univ, Inst Expt Cardiovasc Med, Freiberg, Germany

来源：

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 2018年 / 138卷

基金：

美国国家卫生研究院;

关键词：

Cardiac remodeling; Cardiomyopathy; Sarcomere; Zebrafish; CARDIAC TROPONIN-T; LENGTH-DEPENDENT ACTIVATION; TRANSGENIC MOUSE MODEL; HYPERTROPHIC CARDIOMYOPATHY; IN-VIVO; CONTRACTILE FUNCTION; CA2+ SENSITIVITY; MUTATION; PHOSPHORYLATION; DYSFUNCTION;

D O I：

10.1016/j.pbiomolbio.2018.05.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hypertrophic cardiomyopathy (HCM) is usually manifested by increased myofilament Ca2+ sensitivity, excessive contractility, and impaired relaxation. In contrast, dilated cardiomyopathy (DCM) originates from insufficient sarcomere contractility and reduced cardiac pump function, subsequently resulting in heart failure. The zebrafish has emerged as a new model of human cardiomyopathy with high throughput screening, which will facilitate the discovery of novel genetic factors and the development of new therapies. Given the small hearts of zebrafish, better phenotyping tools are needed to discern different types of cardiomyopathy, such as HCM and DCM. This article reviews the existing models of cardiomyopathy, available morphologic and functional methods, and current understanding of the different types of cardiomyopathy in adult zebrafish. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：116 / 125

页数：10

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