Antiplasmodial and antiviral cyclohexadepsipeptides from the endophytic fungus Pullularia sp BCC 8613

被引：40

作者：

Isaka, Masahiko ^{[1
]}

Berkaew, Pitchapa ^{[1
]}

Intereya, Kamolphan ^{[1
]}

Komwijit, Somjit ^{[1
]}

Sathitkunanon, Thiptiwa ^{[1
]}

机构：

[1] Natl Ctr Genet Engn & Biotechnol BIOTECH, Pathum Thani 12120, Thailand

来源：

TETRAHEDRON | 2007年 / 63卷 / 29期

关键词：

pullularia sp; antiplasmodial activity; antiviral activity; cyclodepsipeptides;

D O I：

10.1016/j.tet.2007.04.062

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new cyclohexadepsipeptides, pullularins A-D, were isolated from the endophytic fungus Pullularia sp. BCC 8613. Structures of these compounds were elucidated by interpretation of NMR spectroscopic and mass spectrometric data. The absolute configurations of amino acid and hydroxy acid residues were determined by HPLC analysis of depsipeptide acid hydrolyzates using a chiral column and Marfey's method. Pullularin A exhibited activities against the malarial parasite Plasmodium falciparum K1 ( IC50 3.6 mu g/mL) and herpes simplex virus type 1 (HSV-1; IC50 3.3 mu g/mL), whereas it showed weak cytotoxicity to Vero cells (IC50 36 mu g/mL). (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6855 / 6860

页数：6

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