IL-15:: targeting CD8+ T cells for immunotherapy

被引：38

作者：

Diab, A

Cohen, AD

Alpdogan, O

Perales, MA

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, BM Transplant Serv, New York, NY 10021 USA

[2] Cornell Univ, Weill Med Coll, New York, NY USA

来源：

CYTOTHERAPY | 2005年 / 7卷 / 01期

关键词：

IL-15; immunotherapy; tumor; vaccine;

D O I：

10.1080/14653240510018037

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

IL-15 is a pleiotropic cytokine that plays an important role in both the innate and adaptive immune system. IL-15 promotes the activation of neutrophils and macrophages, and is critical to DC function. In addition, IL-15 is essential to the development, homeostasis, function and survival of natural killer (NK) cells, NK T (NKT) cells and CD8(+) T cells. Based on these properties, IL-15 has been proposed as a useful cytokine for immunotherapy. It is currently being investigated in settings of immune deficiency, for the in vitro expansion of T and NK cells, as well as an adjuvant for vaccines. In this paper, we will review the targeting of IL-15 for immunotherapy, with a particular emphasis on its effects on CD8(+) T cells.

引用

页码：23 / 35

页数：13

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