Detection of Brain Metastasis With 68Ga-Labeled PSMA Ligand PET/CT A Novel Radiotracer for Imaging of Prostate Carcinoma

被引:47
作者
Chakraborty, Partha Sarathi [1 ]
Kumar, Rajiv [1 ]
Tripathi, Madhavi [1 ]
Das, Chandan Jyoti [2 ]
Bal, Chandrasekhar [1 ]
机构
[1] All India Inst Med Sci, Dept Nucl Med & PET, New Delhi, India
[2] All India Inst Med Sci, Dept Radiodiag, New Delhi, India
关键词
prostate cancer; cerebral metastases; Ga-68-PSMA; PET/CT; CANCER;
D O I
10.1097/RLU.0000000000000709
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Brain metastasis in prostate cancer is rare and not expected at initial presentation especially when the patient is asymptomatic for the same. A 45-year-old male patient undergoing initial evaluation for newly diagnosed prostatic adenocarcinoma was referred to our department for Tc-99m-MDP bone scintigraphy. As part of the study protocol, he also underwent Glu-NH-CO-NH-Lys(Ahx)-[Ga-68(HBED-CC)] (Ga-68-PSMA) PET/CT, which revealed tracer accumulation in brain lesions, apart from localization in the primary, lymph node, and bone metastases. A subsequent MR evaluation confirmed brain metastases.
引用
收藏
页码:328 / 329
页数:2
相关论文
共 9 条
[1]   Comparison of PET/CT and PET/MRI hybrid systems using a 68Ga-labelled PSMA ligand for the diagnosis of recurrent prostate cancer: initial experience [J].
Afshar-Oromieh, A. ;
Haberkorn, U. ;
Schlemmer, H. P. ;
Fenchel, M. ;
Eder, M. ;
Eisenhut, M. ;
Hadaschik, B. A. ;
Kopp-Schneider, A. ;
Roethke, M. .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2014, 41 (05) :887-897
[2]   PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions [J].
Afshar-Oromieh, A. ;
Malcher, A. ;
Eder, M. ;
Eisenhut, M. ;
Linhart, H. G. ;
Hadaschik, B. A. ;
Holland-Letz, T. ;
Giesel, F. L. ;
Kratochwil, C. ;
Haufe, S. ;
Haberkorn, U. ;
Zechmann, C. M. .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2013, 40 (04) :486-495
[3]   [68Ga]Gallium-labelled PSMA ligand as superior PET tracer for the diagnosis of prostate cancer: comparison with 18F-FECH [J].
Afshar-Oromieh, A. ;
Haberkorn, U. ;
Eder, M. ;
Eisenhut, M. ;
Zechmann, C. M. .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2012, 39 (06) :1085-1086
[4]   Technology Insight: monoclonal antibody imaging of prostate cancer [J].
Bander, NH .
NATURE CLINICAL PRACTICE UROLOGY, 2006, 3 (04) :216-225
[5]   Imaging prostate cancer: An update on positron emission tomography and magnetic resonance imaging [J].
Bouchelouche K. ;
Turkbey B. ;
Choyke P. ;
Capala J. .
Current Urology Reports, 2010, 11 (3) :180-190
[6]   Brain Metastases from Prostate Cancer: An 11-Year Analysis in the MRI Era with Emphasis on Imaging Characteristics, Incidence, and Prognosis [J].
Hatzoglou, Vaios ;
Patel, Gita V. ;
Morris, Michael J. ;
Curtis, Kristen ;
Zhang, Zhigang ;
Shi, Weiji ;
Huse, Jason ;
Rosenblum, Marc ;
Holodny, Andrei I. ;
Young, Robert J. .
JOURNAL OF NEUROIMAGING, 2014, 24 (02) :161-166
[7]   Heterogeneity of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Carcinoma with Distant Metastasis [J].
Mannweiler, Sebastian ;
Amersdorfer, Peter ;
Trajanoski, Slave ;
Terrett, Jonathan A. ;
King, David ;
Mehes, Gabor .
PATHOLOGY & ONCOLOGY RESEARCH, 2009, 15 (02) :167-172
[8]   Prostate-specific membrane antigen expression is greatest in prostate adenocarcinoma and lymph node metastases [J].
Sweat, SD ;
Pacelli, A ;
Murphy, GP ;
Bostwick, DG .
UROLOGY, 1998, 52 (04) :637-640
[9]   Brain metastasis from prostate carcinoma - The M. D. Anderson cancer center experience [J].
Tremont-Lukats, IW ;
Bobustuc, G ;
Lagos, GK ;
Lolas, K ;
Kyritsis, AP ;
Puduvalli, VK .
CANCER, 2003, 98 (02) :363-368