A de novo molecular generation method using latent vector based generative adversarial network

被引:245
作者
Prykhodko, Oleksii [1 ,3 ]
Johansson, Simon Viet [1 ,3 ]
Kotsias, Panagiotis-Christos [1 ]
Arus-Pous, Josep [1 ,2 ]
Bjerrum, Esben Jannik [1 ]
Engkvist, Ola [1 ]
Chen, Hongming [1 ,4 ]
机构
[1] AstraZeneca, Biopharmaceut R&D, Discovery Sci, Hit Discovery, Gothenburg, Sweden
[2] Univ Bern, Dept Chem & Biochem, Bern, Switzerland
[3] Chalmers Univ Technol, Dept Comp Sci & Engn, Gothenburg, Sweden
[4] Chem & Chem Biol Ctr, Guangzhou Regenerat Med & Hlth Guangdong Lab, Sci Pk, Guangzhou, Peoples R China
关键词
Molecular design; Autoencoder networks; Generative adversarial networks; Deep learning; DRUG DISCOVERY; INFORMATION; DATABASE; DESIGN;
D O I
10.1186/s13321-019-0397-9
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Deep learning methods applied to drug discovery have been used to generate novel structures. In this study, we propose a new deep learning architecture, LatentGAN, which combines an autoencoder and a generative adversarial neural network for de novo molecular design. We applied the method in two scenarios: one to generate random drug-like compounds and another to generate target-biased compounds. Our results show that the method works well in both cases. Sampled compounds from the trained model can largely occupy the same chemical space as the training set and also generate a substantial fraction of novel compounds. Moreover, the drug-likeness score of compounds sampled from LatentGAN is also similar to that of the training set. Lastly, generated compounds differ from those obtained with a Recurrent Neural Network-based generative model approach, indicating that both methods can be used complementarily.
引用
收藏
页数:13
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