Dup(10q) lacking alpha-satellite DNA in bone marrow cells of a patient with acute myeloid leukemia

被引：26
作者：
Abeliovich, D
Yehuda, O
BenNeriah, S
Kapelushnik, Y
BenYehuda, D
机构：
[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,HADASSAH UNIV HOSP,DEPT HUMAN GENET,IL-91010 JERUSALEM,ISRAEL
[2] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,HADASSAH UNIV HOSP,DEPT BONE MARROW TRANSPLANTAT,IL-91010 JERUSALEM,ISRAEL
[3] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,HADASSAH UNIV HOSP,DEPT HEMATOL,IL-91010 JERUSALEM,ISRAEL
来源：
CANCER GENETICS AND CYTOGENETICS | 1996年 / 89卷 / 01期
关键词：
D O I：
10.1016/0165-4608(95)00300-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A marker chromosome was identified in leukemic cells on an AML patient. The G-banding pattern resembled an i(10q), but its centromeric position was not clear; in some cells it had a telocentric shape, in others a metacentric or acentric shape. The origin of the marker chromosome was confirmed by FISH, using chromosome-10-specific painting. To determine the centromeric position, C-banding and cu-satellite probes were applied in FISH, and none of them gave a positive signal. Despite the absence of the centromeric a-satellite sequences and the constricted feature of the centromere, the essential centromeric activity was retained in this chromosome, namely, the separation of sister chromatids in anaphase.
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页码：1 / 6
页数：6
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