Expression of CD38 in human promyelocytic leukemia HL-60 cell line during differentiation by niacin-related compounds

被引：7
|
作者：
Iwata, K [1 ]
Ogata, S [1 ]
Okumura, K [1 ]
Taguchi, H [1 ]
机构：
[1] Mie Univ, Fac Bioresources, Dept Life Sci, Mol & Cellular Biol Lab, Tsu, Mie 5148507, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2003年 / 67卷 / 08期
关键词：
CD38; niacin; isonicotinic acid; cell differentiation; HL-60;
D O I：
10.1271/bbb.67.1836
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It was found that three niacin-related compounds, isonicotinic acid, nicotinamide, and nicotifiamide N-oxide, induced granulocytic differentiation in HL-60 cells. We investigated the expression of CD38, which catalyzes the synthesis of cyclic ADP-ribose, a Ca2+ mobilizer, during differentiation by niacin-related compounds. It was found that CD38 was induced by isonicotinic acid, whereas nicotinamide and nicotinamide N-oxide containing an amino group did not induce it. The difference in expression of CD38 may provide some useful information for the elucidation of the mechanisms of cell differentiation.
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页码：1836 / 1839
页数：4
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