Electrochemical investigations of cytochrome P450

被引：29

作者：

Shumyantseva, Victoria V. ^{[1
]}

Bulko, Tatiana V. ^{[1
]}

Suprun, Elena V. ^{[1
]}

Chalenko, Yaroslava M. ^{[1
]}

Vagin, Michail Yu. ^{[1
]}

Rudakov, Yurii O. ^{[1
]}

Shatskaya, Marina A. ^{[2
]}

Archakov, Alexander I. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Orekhovich Inst Biomed Chem, Moscow 119121, Russia

[2] Russian State Med Univ, Moscow 117997, Russia

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS | 2011年 / 1814卷 / 01期

关键词：

Hemeproteins; Electrochemical biosensors; Nanocomposite materials; Cytochrome P450; DIRECT ELECTRON-TRANSFER; REDOX THERMODYNAMICS; LIVER-MICROSOMES; PRUSSIAN BLUE; PURIFICATION; SOLVENT; HEMOGLOBIN; BIOSENSORS; REDUCTION; INDUCTION;

D O I：

10.1016/j.bbapap.2010.07.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this paper we summarized our experimental data on the electrochemical reduction of cytochrome P450. Electrode/cytochrome P450 systems were analyzed in terms of the mechanisms underlying P450-catalyzed reactions. Bioelectrocatalysis-based screening of potential substrates or inhibitors of cytochrome P450, stoichiometry of the electrocatalytic cycle, redox thermodynamics and the peroxide shunt pathway were described. Characteristics, performance and potential application of cytochrome P450-electrodes are discussed. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：94 / 101

页数：8

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