Highly enantioselective HPLC separations using the covalently bonded macrocyclic antibiotic, ristocetin A, chiral stationary phase

被引：1

作者：

Ekborg-Ott, KH ^{[1
]}

Liu, YB ^{[1
]}

Armstrong, DW ^{[1
]}

机构：

[1] Univ Missouri, Dept Chem, Rolla, MO 65401 USA

来源：

CHIRALITY | 1998年 / 10卷 / 05期

关键词：

ristocetin A; macrocyclic antibiotic; enantiomeric separations; underivatized amino acids; chiral stationary phase;

D O I：

10.1002/(SICI)1520-636X(1998)10:5<434::AID-CHIR10>3.0.CO;2-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The macrocyclic glycopeptide, ristocetin A, was covalently bonded to a silica gel support and evaluated as a liquid chromatographic (LC) chiral stationary phase (CSP). Over 230 racemates were resolved in either the reversed-phase mode, the normal-phase mode, or the polar-organic mode. The retention behavior and selectivity of this CSP were examined in each mode. Optimization of separations on this column is discussed. The ristocetin A CSP appeared to be complimentary to other glycopeptide CSPs (i.e., vancomycin and teicoplanin). Column stability was excellent. The CSP was not irreversibly altered when going from one mobile phase mode to another. (C) 1998 Wiley-Liss, Inc.

引用

页码：434 / 483

页数：50

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