Sensory TRP channels contribute differentially to skin inflammation and persistent itch

被引:114
作者
Feng, Jing [1 ]
Yang, Pu [1 ]
Mack, Madison R. [2 ]
Dryn, Dariia [1 ,3 ]
Luo, Jialie [1 ]
Gong, Xuan [1 ,4 ]
Liu, Shenbin [1 ]
Oetjen, Landon K. [2 ]
Zholos, Alexander V. [3 ]
Mei, Zhinan [4 ]
Yin, Shijin [4 ]
Kim, Brian S. [2 ]
Hu, Hongzhen [1 ]
机构
[1] Washington Univ, Sch Med, Dept Anesthesiol, Ctr Study Itch, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Med, Div Dermatol,Ctr Study Itch, St Louis, MO 63110 USA
[3] Taras Shevchenko Natl Univ Kyiv, Inst Biol, Dept Biophys, UA-01601 Kiev, Ukraine
[4] South Cent Univ Nationalities, Coll Pharm, Wuhan 430074, Hubei, Peoples R China
来源
NATURE COMMUNICATIONS | 2017年 / 8卷
基金
中国国家自然科学基金; 美国国家卫生研究院;
关键词
ALLERGIC CONTACT-DERMATITIS; ATOPIC-DERMATITIS; NERVE-FIBERS; T-CELLS; IMMUNOLOGICAL MECHANISMS; NEUROGENIC INFLAMMATION; BEHAVIORAL-RESPONSES; PAIN; RECEPTOR; HYPERSENSITIVITY;
D O I
10.1038/s41467-017-01056-8
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Although both persistent itch and inflammation are commonly associated with allergic contact dermatitis (ACD), it is not known if they are mediated by shared or distinct signaling pathways. Here we show that both TRPA1 and TRPV1 channels are required for generating spontaneous scratching in a mouse model of ACD induced by squaric acid dibutylester (SADBE), a small molecule hapten, through directly promoting the excitability of pruriceptors. TRPV1 but not TRPA1 channels protect the skin inflammation, as genetic ablation of TRPV1 function or pharmacological ablation of TRPV1-positive sensory nerves promotes cutaneous inflammation in the SADBE-induced ACD. Our results demonstrate that persistent itch and inflammation are mediated by distinct cellular and molecular mechanisms in a mouse model of ACD. Identification of distinct roles of TRPA1 and TRPV1 in regulating itch and inflammation may provide new insights into the pathophysiology and treatment of chronic itch and inflammation in ACD patients.
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页数:12
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共 58 条
  • [31] RAG-1-DEFICIENT MICE HAVE NO MATURE LYMPHOCYTES-B AND LYMPHOCYTES-T
    MOMBAERTS, P
    IACOMINI, J
    JOHNSON, RS
    HERRUP, K
    TONEGAWA, S
    PAPAIOANNOU, VE
    [J]. CELL, 1992, 68 (05) : 869 - 877
  • [32] NONG YH, 1989, J IMMUNOL, V143, P45
  • [33] Allergic and irritant contact dermatitis Pathophysiology and immunological diagnosis
    Nosbaum, Audrey
    Vocanson, Marc
    Rozieres, Aurore
    Hennino, Anca
    Nicolas, Jean-Francois
    [J]. EUROPEAN JOURNAL OF DERMATOLOGY, 2009, 19 (04) : 325 - 332
  • [34] T cell- and B cell-independent adaptive immunity mediated by natural killer cells
    O'Leary, JG
    Goodarzi, M
    Drayton, DL
    von Andrian, UH
    [J]. NATURE IMMUNOLOGY, 2006, 7 (05) : 507 - 516
  • [35] Recombinant human interferon gamma (Gamma Immunex) in treatment of atopic dermatitis
    Panahi, Yunes
    Davoudi, Seyyed Masoud
    Madanchi, Nima
    Abolhasani, Ehsan
    [J]. CLINICAL AND EXPERIMENTAL MEDICINE, 2012, 12 (04) : 241 - 245
  • [36] CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis
    Qu, Lintao
    Fu, Kai
    Yang, Jennifer
    Shimada, Steven G.
    LaMotte, Robert H.
    [J]. PAIN, 2015, 156 (09) : 1737 - 1746
  • [37] Enhanced excitability of MRGPRA3-and MRGPRD-positive nociceptors in a model of inflammatory itch and pain
    Qu, Lintao
    Fan, Ni
    Ma, Chao
    Wang, Tao
    Han, Liang
    Fu, Kai
    Wang, Yingdi
    Shimada, Steven G.
    Dong, Xinzhong
    LaMotte, Robert H.
    [J]. BRAIN, 2014, 137 : 1039 - 1050
  • [38] A Role for Nociceptive, Myelinated Nerve Fibers in Itch Sensation
    Ringkamp, Matthias
    Schepers, Raf J.
    Shimada, Steven G.
    Johanek, Lisa M.
    Hartke, Timothy V.
    Borzan, Jasenka
    Shim, Beom
    LaMotte, Robert H.
    Meyer, Richard A.
    [J]. JOURNAL OF NEUROSCIENCE, 2011, 31 (42) : 14841 - 14849
  • [39] Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation
    Riol-Blanco, Lorena
    Ordovas-Montanes, Jose
    Perro, Mario
    Naval, Elena
    Thiriot, Aude
    Alvarez, David
    Paust, Silke
    Wood, John N.
    von Andrian, Ulrich H.
    [J]. NATURE, 2014, 510 (7503) : 157 - +
  • [40] TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase
    Shim, Won-Sik
    Tak, Min-Ho
    Lee, Mi-Hyun
    Kim, Minjung
    Kim, Minkyung
    Koo, Jae-Yeon
    Lee, Chang-Hun
    Kim, Misook
    Oh, Uhtaek
    [J]. JOURNAL OF NEUROSCIENCE, 2007, 27 (09) : 2331 - 2337