Expression of stromal cell-derived factor-1 and CXCR4 chemokine receptor mRNAs in cultured rat glial and neuronal cells

被引：109

作者：

Ohtani, Y ^{[1
]}

Minami, M ^{[1
]}

Kawaguchi, N ^{[1
]}

Nishiyori, A ^{[1
]}

Yamamoto, J ^{[1
]}

Takami, S ^{[1
]}

Satoh, M ^{[1
]}

机构：

[1] Kyoto Univ, Fac Pharmaceut Sci, Dept Mol Pharmacol, Kyoto 6068501, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 249卷 / 2-3期

关键词：

stromal cell-derived factor-1; CXCR4 chemokine receptor; messenger RNA; microglia; astrocyte; lipopolysaccharide; rat;

D O I：

10.1016/S0304-3940(98)00425-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The expression of the mRNAs for stromal cell-derived factor-1 alpha and -1 beta (SDF-1 alpha and -1 beta) and their receptor CXCR4 in cultured rat glial and neuronal cells was examined. SDF-1 alpha mRNA was expressed intensely in astrocytes and weakly in neurons, but not in microglia. SDF-1 beta mRNA was expressed weakly in these three types of cells. The expressions of SDF-1 alpha and -1 beta mRNAs in astrocytes were decreased by treatment with LPS (100 ng/ml) for 1-6 h but markedly increased by that for 24-72 h, whereas the expression of SDF-1 beta mRNA in microglia was hardly changed by the treatment for 0.5-6 h, and was decreased by that for 24-48 h. The expression of CXCR4 mRNA was observed in astrocytes, microglia and neurons, and was not altered by LPS treatment. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：163 / 166

页数：4

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