A novel NMR method for screening soluble compound libraries

被引：41

作者：

Hodge, P ^{[1
]}

Monvisade, P ^{[1
]}

Morris, GA ^{[1
]}

Preece, I ^{[1
]}

机构：

[1] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 03期

关键词：

D O I：

10.1039/b008412n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of high resolution diffusion-ordered NMR spectroscopy (HR-DOSY) to detect association between a soluble polymer and different components of small libraries of soluble compounds is illustrated for libraries bindingrespectively to weakly acidic and weakly basic polymers.

引用

页码：239 / 240

页数：2

共 20 条

[1]

BATZ HG, 1976, MAKROMOL CHEM, V177, P683

[2] Diffusion edited NMR: Screening compound mixtures by affinity NMR to detect binding ligands to vancomycin [J].

Bleicher, K ;

Lin, MF ;

Shapiro, MJ ;

Wareing, JR .

JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (23) :8486-8490

[3]

BOWYER PJ, 2000, 41 ENC AS CA

[4] New catalysts and conditions for a C-H insertion reaction identified by high throughput catalyst screening [J].

Burgess, K ;

Lim, HJ ;

Porte, AM ;

Sulikowski, GA .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (02) :220-222

[5] The combinatorial synthesis of chiral phosphine ligands [J].

Gilbertson, SR ;

Wang, XF .

TETRAHEDRON LETTERS, 1996, 37 (36) :6475-6478

[6]

JOHNSON CS, 1999, PROG NMR SPECTROSC, V34, P204

[7] Highly selective chiral recognition on polymer supports:: preparation of a combinatorial library of dihydropyrimidines and its screening for novel chiral HPLC ligands [J].

Lewandowski, K ;

Murer, P ;

Svec, F ;

Fréchet, JMJ .

CHEMICAL COMMUNICATIONS, 1998, (20) :2237-2238

[8] Mixture analysis in combinatorial chemistry. Application of diffusion-resolved NMR spectroscopy [J].

Lin, MF ;

Shapiro, MJ .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (21) :7617-7619

[9] Diffusion-edited NMR-affinity NMR for direct observation of molecular interactions [J].

Lin, MF ;

Shapiro, MJ ;

Wareing, JR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (22) :5249-5250

[10] Screening mixtures by affinity NMR [J].

Lin, MF ;

Shapiro, MJ ;

Wareing, JR .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (25) :8930-8931

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