18F-FDG-PET/CT in radiation therapy-induced parotid gland inflammation

被引:7
作者
Mouminah, Alaa [1 ,2 ]
Borja, Austin J. [1 ,3 ]
Hancin, Emily C. [1 ,4 ]
Chang, Yu Cheng [2 ]
Werner, Thomas J. [1 ]
Swisher-McClure, Samuel [5 ]
Korostoff, Jonathan [2 ]
Alavi, Abass [1 ]
Revheim, Mona-Elisabeth [1 ,6 ,7 ]
机构
[1] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Dent Med, Philadelphia, PA 19104 USA
[3] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
[4] Temple Univ, Lewis Katz Sch Med, Philadelphia, PA 19122 USA
[5] Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA
[6] Oslo Univ Hosp, Div Radiol & Nucl Med, Oslo, Norway
[7] Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway
来源
EUROPEAN JOURNAL OF HYBRID IMAGING | 2020年 / 4卷 / 01期
关键词
PET; CT; 18F-FDG; Radiation therapy; Parotid gland; Parotid gland inflammation; Head and neck cancer; PROTON THERAPY; NECK; HEAD; PET/CT; DIAGNOSIS;
D O I
10.1186/s41824-020-00091-x
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Background(18)F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) is used in the clinical management of oncologic and inflammatory pathologies. It may have utility in detecting radiotherapy (RT)-induced damage of oral tissues. Thus, the aim of the present study was to use FDG-PET/CT to evaluate parotid gland inflammation following RT in patients with head and neck cancer (HNC).MethodsThis retrospective study included patients with HNC treated with photon, proton, or combined photon/proton RT, in addition to chemotherapy. All patients received FDG-PET/CT imaging pre-treatment and 3months post-treatment. The average mean standardized uptake value (Avg SUVmean) and the average maximum standardized uptake value (Avg SUVmax) of the left and right parotid glands were determined by global assessment of FDG activity using OsiriX MD software. A two-tailed paired t test was used to compare Avg SUVmean and Avg SUVmax pre- and post-RT.ResultsForty-seven HNC patients were included in the study. Parotid gland Avg SUVmean was significantly higher at 3months post-treatment than pre-treatment (p < 0.05) in patients treated with photon RT, but no significant differences were found between pre- and post-treatment Avg SUVmean in patients treated with proton RT or combined photon/proton RT.ConclusionOur results suggest that photon RT may cause radiation-induced inflammation of the parotid gland, and that proton RT, which distributes less off-target radiation, is a safer treatment alternative.
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页数:10
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