Extending the Human Connectome Project across ages: Imaging protocols for the Lifespan Development and Aging projects

被引：279

作者：

Harms, Michael P. ^{[1
]}

Somerville, Leah H. ^{[6
,7
]}

Ances, Beau M. ^{[2
]}

Andersson, Jesper ^{[8
]}

Barch, Deanna M. ^{[1
,3
,5
]}

Bastiani, Matteo ^{[8
]}

Bookheimer, Susan Y. ^{[11
]}

Brown, Timothy B. ^{[3
]}

Buckner, Randy L. ^{[13
,14
]}

Burgess, Gregory C. ^{[1
]}

Coalson, Timothy S. ^{[4
]}

Chappell, Michael A. ^{[8
,9
]}

Dapretto, Mirella ^{[11
]}

Douaud, Gwena Elle ^{[8
]}

Fischl, Bruce ^{[15
]}

Glasser, Matthew F. ^{[4
,16
]}

Greve, Douglas N. ^{[13
]}

Hodge, Cynthia ^{[1
]}

Jamison, Keith W. ^{[17
]}

Jbabdi, Saad ^{[8
]}

Kandala, Sridhar ^{[1
]}

Li, Xiufeng ^{[18
]}

Mair, Ross W. ^{[13
]}

Mangia, Silvia ^{[18
]}

Marcus, Daniel ^{[3
]}

Mascali, Daniele ^{[20
,21
]}

Moeller, Steen ^{[18
]}

Nichols, Thomas E. ^{[8
,10
,22
]}

Robinson, Emma C. ^{[23
]}

Salat, David H. ^{[8
]}

Smith, Stephen M. ^{[8
]}

Sotiropoulos, Stamatios N. ^{[8
,24
]}

Terpstra, Melissa ^{[18
]}

Thomas, Kathleen M. ^{[19
]}

Tisdall, M. Dylan ^{[25
]}

Ugurbil, Kamil ^{[18
]}

van der Kouwe, Andre ^{[13
,14
]}

Woods, Roger P. ^{[11
,12
]}

Zollei, Lilla

Van Essen, David C. ^{[4
]}

Yacoub, Essa ^{[18
]}

机构：

[1] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dept Neurosci, St Louis, MO USA

[5] Washington Univ, Dept Psychol & Brain Sci, St Louis, MO USA

[6] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA

[7] Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA

[8] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford Ctr Funct Magnet Resonance Imaging Brain F, Wellcome Ctr Integrat Neuroimaging, Oxford, England

[9] Univ Oxford, Inst Biomed Engn, Dept Engn Sci, Oxford, England

[10] Univ Oxford, Nuffield Dept Populat Hlth, Oxford Big Data Inst, Li Ka Shing Ctr Hlth Informat & Discovery, Oxford, England

[11] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90095 USA

[12] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA

[13] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Boston, MA 02115 USA

[14] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02115 USA

[15] MIT, Comp Sci & Artificial Intelligence Lab, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[16] St Lukes Hosp, St Louis, MO USA

[17] Weill Cornell Med Coll, Dept Radiol, New York, NY USA

[18] Univ Minnesota, Ctr Magnet Resonance Res, Minneapolis, MN USA

[19] Univ Minnesota, Inst Child Dev, 51 E River Rd, Minneapolis, MN 55455 USA

[20] Museo Stor Fis, Ctr Fermi, Rome, Italy

[21] Ctr & Ric Enrico Fermi, Rome, Italy

[22] Univ Warwick, Dept Stat, Coventry, W Midlands, England

[23] Kings Coll London, Dept Biomed Engn, London, England

[24] Univ Nottingham, Sch Med, Sir Peter Mansfield Imaging Ctr, Nottingham, England

[25] Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA

来源：

NEUROIMAGE | 2018年 / 183卷

基金：

英国工程与自然科学研究理事会;

关键词：

Connectomics; Resting-state; Functional connectivity; Task; Diffusion; Perfusion; Development; Aging; Lifespan; SPIN-LABELING PERFUSION; CEREBRAL-BLOOD-FLOW; RESTING-STATE FMRI; IN-DIFFUSION MR; MOTION CORRECTION; HEAD MOTION; VOLUMETRIC NAVIGATORS; BRAIN MORPHOMETRY; ACQUISITION; SIGNAL;

D O I：

10.1016/j.neuroimage.2018.09.060

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Human Connectome Projects in Development (HCP-D) and Aging (HCP-A) are two large-scale brain imaging studies that will extend the recently completed HCP Young-Adult (HCP-YA) project to nearly the full lifespan, collecting structural, resting-state fMRI, task-fMRI, diffusion, and perfusion MRI in participants from 5 to 100+ years of age. HCP-D is enrolling 1300+ healthy children, adolescents, and young adults (ages 5-21), and HCP-A is enrolling 1200+ healthy adults (ages 36-100+), with each study collecting longitudinal data in a subset of individuals at particular age ranges. The imaging protocols of the HCP-D and HCP-A studies are very similar, differing primarily in the selection of different task-fMRI paradigms. We strove to harmonize the imaging protocol to the greatest extent feasible with the completed HCP-YA (1200+ participants, aged 22-35), but some imaging-related changes were motivated or necessitated by hardware changes, the need to reduce the total amount of scanning per participant, and/or the additional challenges of working with young and elderly populations. Here, we provide an overview of the common HCP-D/A imaging protocol including data and rationales for protocol decisions and changes relative to HCP-YA. The result will be a large, rich, multi-modal, and freely available set of consistently acquired data for use by the scientific community to investigate and define normative developmental and aging related changes in the healthy human brain.

引用

页码：972 / 984

页数：13

共 93 条

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