Glioblastoma in Patients With Multiple Sclerosis

被引:2
作者
Berkman, Jillian M. [1 ,2 ]
Nakhate, Vihang [1 ,2 ]
Gonzalez Castro, L. Nicolas [3 ]
机构
[1] Brigham & Womens Hosp, Dept Neurol, 75 Francis St, Boston, MA 02115 USA
[2] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA
[3] Dana Farber Canc Inst, Ctr Neurooncol, 450 Brookline Ave, Boston, MA 02115 USA
关键词
Glioma; glioblastoma; multiple sclerosis; autoimmune diseases of the nervous system; demyelinating diseases; MAGNETIC-RESONANCE-SPECTROSCOPY; CENTRAL-NERVOUS-SYSTEM; T2-FLAIR MISMATCH; ADVANCED MELANOMA; UNITED-STATES; PRIMARY BRAIN; GLIOMAS; TUMORS; BIOMARKER; THERAPY;
D O I
10.1177/19418744221106003
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background Although rare, the co-occurrence of multiple sclerosis (MS) and glioma poses unique challenges in terms of diagnosis and management for both neurologists and neuro-oncologists. Methods Here we report on a single-center cohort of four patients with a diagnosis of multiple sclerosis who developed gliomas. Results Our cohort reflects the epidemiology of glioma in terms of the relative frequency of IDH-wildtype and IDH-mutant cases. The patients in 3 out of the 4 cases presented did not develop their tumors in areas of pre-existing demyelinating lesions. Conclusions We did not find evidence to support the hypothesis that chronic gliosis from demyelinating plaques may serve as a substrate for secondary induction of a glial neoplasm. In our Discussion, we provide recommendations for distinguishing neoplastic from demyelinating lesions, review the evidence for demyelination as a risk factor for gliomagenesis, and highlight important considerations for the concurrent management of glioma and MS.
引用
收藏
页码:607 / 616
页数:10
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