Asymmetric Dimethylarginine and Augmentation Index in Newly Diagnosed Patients With Hypertension

被引：16

作者：

Cakar, Mustafa ^{[1
]}

Bulucu, Fatih ^{[1
]}

Karaman, Murat ^{[1
]}

Ahmet, Seyit ^{[1
]}

Kurt, Omer ^{[1
]}

Balta, Sevket ^{[2
]}

Demirkol, Sait ^{[2
]}

Sarlak, Hakan ^{[1
]}

Akhan, Muharrem ^{[1
]}

Altun, Battal ^{[3
]}

Yaman, Halil ^{[4
]}

Arslan, Erol ^{[1
]}

Demirbas, Seref ^{[1
]}

Saglam, Kenan ^{[1
]}

机构：

[1] Gulhane Med Fac, Dept Internal Med, Ankara, Turkey

[2] Gulhane Med Fac, Dept Cardiol, Ankara, Turkey

[3] Kasimpasa Hosp, Dept Internal Med, Istanbul, Turkey

[4] Gulhane Med Fac, Dept Clin Biochem, Ankara, Turkey

来源：

ANGIOLOGY | 2015年 / 66卷 / 01期

关键词：

arterial stiffness; pulse wave velocity; central aortic pressure; augmentation index; ADMA; CRP; CARDIOVASCULAR RISK-FACTORS; PULSE-WAVE VELOCITY; C-REACTIVE PROTEIN; ARTERIAL STIFFNESS; BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; SMOKING-CESSATION; OXIDATIVE STRESS; ALL-CAUSE; MORTALITY;

D O I：

10.1177/0003319713513145

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Pulse wave velocity (PWV), augmentation index (Aix), and central aortic pressure (CAP) are arterial stiffness markers of endothelial dysfunction (ED). We investigated the relationship between arterial stiffness parameters and asymmetric dimethylarginine (ADMA; a marker of ED), in newly diagnosed patients with hypertension (n = 101; 61 females). These patients were investigated in accordance with the recommendations of hypertension guidelines. Arterial stiffness was measured, and serum ADMA and C-reactive protein (CRP; a marker of inflammation) levels were determined. In both women and men, there was no difference in terms of age, body mass index, systolic and diastolic blood pressures, PWV, CAP and the levels of ADMA, while Aix and CRP levels were significantly higher in women (P = .004, P = .046, respectively). In the whole group, ADMA levels correlated with Aix (Pearson r = .237, P = .024). Our findings provide further evidence of a link between arterial stiffness and ED in newly diagnosed patients with hypertension.

引用

页码：43 / 48

页数：6

共 38 条

[1] The Relationship Between Some of the Cardiovascular Risk Factors and Arterial Stiffness Parameters in Essentially Hypertensive Patients [J].