The formation of lipid droplets: possible role in the development of insulin resistance/type 2 diabetes

被引：18

作者：

Olofsson, Sven-Olof ^{[1
]}

Andersson, Linda ^{[1
]}

Haversen, Liliana ^{[1
]}

Olsson, Christina ^{[1
]}

Myhre, Susanna ^{[1
]}

Rutberg, Mikael ^{[1
]}

Mobini, Reza ^{[1
]}

Li, Lu ^{[1
]}

Lu, Emma ^{[1
]}

Boren, Jan ^{[1
]}

Bostrom, Pontus ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgenska Acad, Dept Mol & Clin Med, Sahlgrenska Ctr Metab & Cardiovasc Res, Gothenburg, Sweden

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2011年 / 85卷 / 05期

关键词：

MEMBRANE-FUSION; SNARE;

D O I：

10.1016/j.plefa.2011.04.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neutral lipids are stored in so-called lipid droplets, which are formed as small primordial droplets at microsomal membranes and increase in size by a fusion process. The fusion is catalyzed by the SNARE proteins SNAP23, syntaxin-5 and VAMP4. SNAP23 is involved in the insulin dependent translocation of GLUT4 to the plasma membrane, and has an important role in the development of insulin resistance. Thus fatty acids relocalize SNAP23 from the plasma membrane (and the translocation of GLUT 4) to the interior of the cell giving rise to insulin resistance. Moreover this relocalization is seen in skeletal muscles biopsies from patients with type 2 diabetes compared to matched control. Thus a missorting of SNAP23 is essential for the development of insulin resistance. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：215 / 218

页数：4

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