Is the fertility treatment itself a risk factor for early pregnancy loss?

被引：18
|
作者：
Brandes, M. [1 ]
Verzijden, J. C. M. [2 ]
Hamilton, C. J. C. M. [1 ]
de Weys, N. P. C. [1 ]
de Bruin, J. P. [1 ]
Bots, R. S. G. M. [3 ]
Nelen, W. L. D. M. [2 ]
Kremer, J. A. M. [2 ]
机构：
[1] Jeroen Bosch Hosp, Dept Obstet & Gynecol, Shertogenbosch, Netherlands
[2] Radboud Univ Nijmegen Med Ctr, Dept Obstet & Gynecol, Nijmegen, Netherlands
[3] St Elizabeth Hosp, Dept Obstet & Gynecol, Tilburg, Netherlands
来源：
REPRODUCTIVE BIOMEDICINE ONLINE | 2011年 / 22卷 / 02期
关键词：
early pregnancy loss; frozen embryo transfer; infertility; IVF; miscarriage; ASSISTED REPRODUCTIVE TECHNOLOGY; SPONTANEOUS-ABORTION; RECURRENT MISCARRIAGE; SUBFERTILE COUPLES; MATERNAL AGE; BODY-MASS; INFERTILITY; IVF; ENDOMETRIOSIS; FERTILIZATION;
D O I：
10.1016/j.rbmo.2010.10.013
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
This longitudinal multicentre cohort study aimed to identify the role of the conception mode in infertile couples with an early pregnancy loss (EPL). All couples referred to the fertility clinic for the first time in the period 2002-2006 because of infertility were followed up to their first clinical pregnancy (n = 1809). EPL was the outcome of 286 (15.8%) pregnancies. EPL rates for the different conception modes were as follows: spontaneous 14.5% (125/864), ovulation induction 15.8% (42/266), intrauterine insemination 25.0% (5/20), intrauterine insemination combined with ovarian stimulation 18.2% (37/203), IVF 16.3% (31/190), intracytoplasmic sperm injection (ICSI) 14.9% (30/202) and frozen embryo transfer (FET) 26.2% (16/61). After adjusting for female age, male age, hospital, obstetric history, female smoking habit, male alcohol use, menstrual cycle type and infertility diagnosis, the EPL rate after FET was significantly increased (odds ratio 2.2, 95% CI 1.14-4.19) compared with spontaneous conception. Embryo quality was comparable in fresh and frozen embryos. Other fertility treatments showed no increased miscarriage rate. Therefore, it is concluded that even after adjustment for confounding factors conception through FET remained an independent risk factor for EPL. Other modes of conception were not related with EPL. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：192 / 199
页数：8
相关论文
共 50 条
  • [1] Is the fertility treatment itself a risk factor for early pregnancy loss?
    Torrealday, Saioa
    CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, 2014, 26 (03) : 174 - 180
  • [2] Is the fertility treatment itself a risk factor for early pregnancy loss?
    Hamilton, C.
    Brandes, M.
    Verzijden, J. C. M.
    de Weys, N. P. C.
    de Bruin, J. P.
    Bots, R. S. G. M.
    Nelen, W. L. D. M.
    Kremer, J. A. M.
    HUMAN REPRODUCTION, 2010, 25 : I169 - I169
  • [3] Genetic risk factor for unexplained recurrent early pregnancy loss
    Nelen, WLDM
    Steegers, EAP
    Eskes, TKAB
    Blom, HJ
    LANCET, 1997, 350 (9081): : 861 - 861
  • [4] Obesity is a risk factor for early pregnancy loss after IVF or ICSI
    Fedorcsák, P
    Storeng, R
    Dale, PO
    Tanbo, T
    Åbyholm, T
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2000, 79 (01) : 43 - 48
  • [5] Elevated coagulation factor VIII and the risk for recurrent early pregnancy loss
    Dossenbach-Glaninger, A
    van Trotsenburg, M
    Krugluger, W
    Dossenbach, MR
    Oberkanins, C
    Huber, J
    Hopmeier, P
    THROMBOSIS AND HAEMOSTASIS, 2004, 91 (04) : 694 - 699
  • [6] FIRST TRIMESTER SUBCHORIONIC HEMATOMA AND EARLY PREGNANCY LOSS IN PATIENTS UNDERGOING FERTILITY TREATMENT
    Dadoun, Simon Eliahou
    Yang, Liubin
    Casey, Sarah
    Gibbons, William
    Detti, Laura
    FERTILITY AND STERILITY, 2023, 120 (04) : E169 - E170
  • [7] Early diagnosis of cervical pregnancy: The most important factor for preservation of fertility with conservative treatment
    Sainz, J. A.
    Serrano, R.
    Borrero, C.
    Soto, F.
    Marin, A.
    Turmo, E.
    Garrido, R.
    CLINICA E INVESTIGACION EN GINECOLOGIA Y OBSTETRICIA, 2011, 38 (01): : 23 - 26
  • [8] Low anti-Mullerian hormone level is not a risk factor for early pregnancy loss in IVF/ICSI treatment
    Peuranpaa, P.
    Hautamaki, H.
    Halttunen-Nieminen, M.
    Hyden-Granskog, C.
    Tiitinen, A.
    HUMAN REPRODUCTION, 2020, 35 (03) : 504 - 515
  • [9] HYPERHOMOCYSTEINEMIA - A RISK FACTOR IN WOMEN WITH UNEXPLAINED RECURRENT EARLY-PREGNANCY LOSS
    WOUTERS, MGAJ
    BOERS, GHJ
    BLOM, HJ
    TRIJBELS, FJM
    THOMAS, CMG
    BORM, GF
    STEEGERSTHEUNISSEN, RPM
    ESKES, TKAB
    FERTILITY AND STERILITY, 1993, 60 (05) : 820 - 825
  • [10] Treatment with enoxaparin adapted to the fertility program in women with early recurrent pregnancy loss and thrombophilia.
    Sarto, A
    Rocha, M
    Geller, M
    Capmany, C
    Martinez, M
    Quintans, C
    Donaldson, M
    Pasqualini, RS
    MEDICINA-BUENOS AIRES, 2001, 61 (04) : 406 - 412
12345