Activity-based protein profiling: From enzyme chemistry

被引：948
作者：
Cravatt, Benjamin F. [1 ,2 ]
Wright, Aaron T. [1 ,2 ]
Kozarich, John W. [3 ]
机构：
[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA
[3] Activx Biosci, La Jolla, CA 92037 USA
来源：
ANNUAL REVIEW OF BIOCHEMISTRY | 2008年 / 77卷
关键词：
affinity label; mass spectrometry; proteomics;
D O I：
10.1146/annurev.biochem.75.101304.124125
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Genome sequencing projects have provided researchers with a complete inventory of the predicted proteins produced by eukaryotic and prokaryotic organisms. Assignment of functions to these proteins represents one of the principal challenges for the field of proteomics. Activity-based protein profiling (ABPP) has emerged as a powerful chemical proteomic strategy to characterize enzyme function directly in native biological systems on a global scale. Here, we review the basic technology of AMP, the enzyme classes addressable by this method, and the biological discoveries attributable to its application.
引用
收藏
页码：383 / 414
页数：32
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