Clocks and switches:: bacterial gene regulation by DNA adenine methylation

被引：85

作者：

Low, David A. ^{[1
]}

Casadesus, Josep ^{[2
]}

机构：

[1] Univ Calif Santa Barbara, Santa Barbara, CA 93106 USA

[2] Univ Seville, Fac Biol, Dept Genet, E-41080 Seville, Spain

来源：

CURRENT OPINION IN MICROBIOLOGY | 2008年 / 11卷 / 02期

关键词：

D O I：

10.1016/j.mib.2008.02.012

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

N-6 methylation in adenosine moieties causes changes in DNA structure and can modulate DNA-protein interactions. In both alpha-Proteobacteria and gamma- Proteobacteria, postreplicative formation of N-6-methyl-adenine regulates transcription of specific genes and provides two general types of controls: (i) clock-like controls that permit transient gene transcription during a specific stage of DNA replication; (ii) switch-like controls in which transcription is regulated by a DNA methylation pattern. DNA adenine methylation may also regulate gene expression by affecting nucleoid topology. Recent transcriptomic studies have unveiled novel cases of genes regulated by DNA adenine methylation, including virulence genes of bacterial pathogens.

引用

页码：106 / 112

页数：7